Keio University

Wataru Suda

Kenya Honda

Koji Atarashi

Masahira Hattori

Seiko Narushima

Keiko Mitobe

Takaaki Kawaguchi

Munehiro Furuichi

The result of orally administering saliva derived from a Crohn's disease patient or an ulcerative colitis patient to germ-free mice has revealed that Th1 cells markedly increased in the colons. Further, from the bacterial microbiota in the intestines of the mice in which such an increase in Th1 cells were observed, bacteria have been successfully isolated which caused strong Th1 cell induction in the colon upon intestinal colonization.

Bacterium capable of inducing TH1 cells

With the aim of proving an antibacterial composition against oral bacteria and the like capable of inducing Th1 cell proliferation or activation in an intestinal tract, the present inventors have found out that bacteria that suppress colonization and the like of the oral bacteria and the like in the intestinal tract are present in an intestinal microbiota. Moreover, the present inventors have succeeded in isolating intestinal bacteria that suppress intestinal colonization and the like of oral bacteria and the like.

Anti-bacterial composition against TH1 cell-inducing bacteria

Growing community of inventors

Tokyo, Japan

Wataru Suda