Kyorin Pharmaceutical Co., Ltd.

Wataru Hori

Yasushi Kohno

Kazuhiko Kuriyama

Kiyoaki Tanaka

Jun Asano

Shigeki Isogai

Aminophosphonic acid derivatives (e.g., 2-amino-5-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]-2-methylpentylphosphonate monoester) are represented by the following general formula (1): and act as effective S1P receptor modulators while posing less side effects.

Aminophosphonic acid derivative, salt thereof, and modulator of S1P receptor

Aminophosphonic acid derivatives, addition salts thereof and S1P receptor modulators

The invention provides novel (2S)-2-ethylphenylpropanoic acid derivatives that bind to the receptor as ligands of human peroxisome proliferator-activated receptor (PPAR) &#x3b1; to activate and exhibit lipid-lowering effect, inhibitory effect on the arteriosclerosis, antiobesity effect, blood glucose-lowering effect, etc., their addition salts, and their medicinal compositions. (2S)-2-Ethylphenylpropanoic acid derivatives represented by a general formula (1) [wherein R1 denotes a halogen atom or trifluoromethyl group, R2 denotes a hydrogen atom, halogen atom or trifluoromethyl group, and, when R2 denotes a hydrogen atom, R3 denotes a halogen atom or trifluoromethyl group and, when R2 denotes a halogen atom or trifluoromethyl group, R3 denotes a hydrogen atom, halogen atom or trifluoromethyl group], and their addition salts.

(2S)-2-ethylphenylpropionic acid derivative

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Tochigi, Japan

Wataru Hori