Kyoto University

Kyowa Medex Co., Ltd.

Asama Chemical Co., Ltd.

Maruha Nichiro Holdings, Inc.

Hitachi Chemical Diagnostics Systems Co., Ltd.

Wataru Hashimoto

Kousaku Murata

Mizuo Yajima

Noriyuki Ogawa

Takehide Kimura

Yasuki Fukuda

Fumi Umehara

Keiko Matsutani

Hiroshi Oda

Keishi Iohara

Shigeyuki Kawai

Bunzo Mikami

Hiroyuki Takeda

Fuminori Yoneyama

Akihito Ochiai

The present invention provides a method for measuring glycated hemoglobin in a sample, which comprises directly oxidizing glycated hemoglobin in a sample, and then measuring a substance produced or consumed by the oxidation; and a method for measuring glycated hemoglobin in a sample, which comprises directly oxidizing glycated hemoglobin in a sample using an enzyme, and then measuring a substance produced or consumed by the oxidation. A method for measuring glycated hemoglobin of the present invention is useful for diagnosing lifestyle-related disease such as diabetes mellitus.

Method for measuring glycated hemoglobin

The present invention provides a protein comprising an amino acid sequence in which arginine at position 61 of a protein comprising the amino acid sequence represented by SEQ ID NO: 1 is substituted to an amino acid selected from the group consisting of glycine, alanine, valine, leucine, serine, threonine, proline, cysteine, methionine, asparagine, glutamine, and aspartic acid; and a method for measuring a glycated hemoglobin in a sample, wherein the method comprises reacting a glycated hemoglobin in a sample with a protease to produce a glycated hexapeptide, then reacting the produced glycated hexapeptide with the aforementioned protein, and measuring a substance produced or consumed by the reaction.

Glycated hexapeptide oxidase and use thereof

An object of the present invention is to provide a method for producing ethanol from polysaccharide alginate contained in a large amounts in brown algae, using the alginate assimilation capacity of thesp. strain A1 and the strong ethanol production capacity of bacteria such as. Specifically, a method for producing ethanol using alginate as a raw material comprises causing genes encoding proteins and enzymes involved insp. strain A1-derived alginate assimilation and genes encoding enzymes involved in ethanol production to co-exist in a single microorganism and then culturing the microorganism in a medium containing alginate.

Ethanol production from ocean biomass

An antimicrobial composition for eucaryotic microorganisms and method of suppressing the growth of eucaryotic microorganisms requires a procaryotic DNA extract. The antimicrobial composition is effective against numerous types of eucaryotic microorganisms and can be safely added to food and cosmetic products.

Antimicrobial agents for eucaryotic microorganisms and methods of growth suppression of eucaryotic microorganisms using these agents

Antimicrobial agents for eucaryotic microorganisms and methods of growth

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Kyoto, Japan

Wataru Hashimoto