Biopath Automation, LLC

Ethicon Endo-surgery, Inc.

Origin Medsystems, Inc.

The Cleveland Clinic Foundation

Baxter International Inc.

Idx Medical, Ltd.

Maquet Cardiovascular LLC

Sakura Finetek U.s.a., Inc.

Cardiovascular Technologies, Inc.

Tendon Technology, Ltd.

Other

Atricure, Inc.

Medtronic, Inc.

Ethicon, Gmbh

Guidant Corporation

Warren P Williamson, Iv

Paul A Spence

Craig B Berky

Thomas J Ward

Mark S Ortiz

George T Christakis

Stephen P Whitlatch

David C Yates

Richard I Brown

Delos M Cosgrove, Iii

George A Keller

Thomas W Huitema

Matthew J Huddleston

Kenneth E Hughes

Anthony A Boiarski

James H Chambers

Mark Fogelberg

Mark T Byrne

Cecil R Robinson

Douglas P Allen

Kenneth S Wales

Matthew R Otten

Carl R Coleman

Lawrence M Lubbers

Bryan Dale Knodel

Richard P Nuchols

Joseph E Young

Jesse J Kuhns

T Michael Dennehey

Jeremy David Jarrett

Jason Iain Glithero

Peter F Staats

Matthew J Winkler

William J Christy

Everett Dennison

Amit D Shah

Dominic P DiNovo

Timothy J Duffy

Gregory T Pauley

Scott L Jones

Mark Goldin

Albert H Pharis, Jr

Richard W Dapson

Anil K Nalagatla

James Walden Voegele

Jonathan L Podmore

Michael Francis Wei

Thomas A Kramer

John W Davis

Andrew F Knight

Geoffrey H Willis

Brian Schumacher

Peter L Callas

Arthur S Chapman

Michael K Banbury

Carlos A Saez

Timothy J McCoy

Paul M Di Perna

Jillian E Banbury

Perry DeFazio

Terence Lee Murphy

Nickola Symone Lewis

Rebeccah P Quam

Bradley D Blackwood

Michael D Hooven

Todd A Hall

Jack E Smith

Harry Leonard Green, Ii

Darrel M Powell

Michael W Goldenbogen

E David Allen

Jonathan Eric Turner

Leo J Nolan

E Dale VanHoose

Delbert Ted Leimbach

Marty J Warnecke

James R Christy

Jason Iain Gilthero

David J Drachman

George T Chistakis

Steven Burnett

Stephen P Whitlach

Keith A Kuisick

Ernest D VanHoose

Chadd R Tyler

Stephen Whitlach

Jonathan E Turner

A histologic tissue sample support device includes a tissue cassette, a frame, a lid, and a frame-cassette connector. The tissue cassette formed of a first material has a recess including a body with at least one side wall and a bottom wall and is formed of material that can be successfully sectioned in a microtome and is resistant to degradation from solvents and chemicals used to fix, process and stain tissue. The tissue cassette is movably coupled to the frame by a frame-cassette connector. The lid is coupled to the frame. The lid and the tissue cassette are capable of moving from a first position to a second position with respect to the frame, and in the second position the bottom wall and at least a portion of the side wall extend beyond a bottom edge of the frame for sectioning in a microtome.

Sectionable cassette and embedding frame with connectors, and methods for preparing biopsy tissue samples

A sectionable tissue sample support structure including a gel compound formed into a self supporting geometric shape for retention and orientation of at least one tissue sample during a histopathology process including processing, embedding and microtome slicing of the tissue sample. A method of orienting, processing, embedding and microtome slicing a tissue sample using a gel compound preformed into a self supporting geometric shape. A combination including the sectionable tissue sample support structure and a package containing the sectionable tissue sample support structure.

Microtome sectionable gel support structure and methods

A method for preparing one or more biopsy tissue samples for histological examination includes positioning a tissue sample in a tissue cassette, closing a peripheral portion of a frame including a cassette lid, and moving the lid and the tissue cassette from a first position to a second position. The tissue cassette is coupled to a frame by a frame-cassette connector and moving the lid and the tissue cassette from the first position to the second position includes breaking the frame-cassette connector. The tissue cassette has a recess including at least one side wall and a bottom wall and is formed of a first material that can be successfully sectioned in a microtome. In the second position, the bottom wall and at least a portion of the side wall extend downwardly beyond a bottom edge of the frame for sectioning in the microtome.

A histologic tissue sample support device includes a tissue cassette a frame, and a lid. The tissue cassette has a recess including a body with at least one side wall and a bottom wall and is formed of material that can be successfully sectioned in a microtome and is resistant to degradation from solvents and chemicals used to fix, process and stain tissue. The tissue cassette is movably coupled to the frame. The lid is separably coupled to a peripheral portion of the frame. When the lid is separated from the peripheral portion, the lid and the tissue cassette are capable of moving from a first position to a second position with respect to the frame, and in the second position the bottom wall and at least a portion of the side wall extend beyond a bottom edge of the frame for sectioning in the microtome.

Sectionable cassette and embedding frame with tissue immobilizing separable lid, and methods for preparing biopsy tissue samples

A histologic tissue sample support device includes a tissue cassette, a frame, and a lid. The tissue cassette has a recess including a body with at least one side wall and a bottom wall and is formed of material that can be successfully sectioned in a microtome and is resistant to degradation from solvents and chemicals used to fix, process and stain tissue. The tissue cassette is movably coupled to the frame by a frame-cassette connector. The lid is coupled to a peripheral portion of the frame by a lid-frame connector. The lid and the tissue cassette are capable of moving from a first position to a second position with respect to the frame, and in the second position the bottom wall and at least a portion of the side wall extend beyond a bottom edge of the frame for sectioning in a microtome.

A clamp having at least first and second elongate clamping portions adapted to be placed on opposite sides of the hollow anatomical structure. The first and second elongate clamping portions respectively include ends coupled together with respective resilient urging members configured to urge at least one of the first and second elongate clamping portions toward the other of the first and second elongate clamping portions from an open position into a clamping position to occlude the hollow anatomical structure. The clamp includes tissue ingrowth structure on the clamping portions.

Apparatus and methods for occluding a hollow anatomical structure

A method of occluding an appendage of the heart with a clamp including at least first and second elongate clamping portions, the first and second elongate clamping portions including tissue engaging surfaces that promote tissue ingrowth. The method includes implanting the clamp by positioning the first and second elongate clamping portions on opposite sides of the appendage. At least one of the first or second elongate clamping portions is biased toward the other of the first and second elongate clamping portions to place the clamp into a clamping position on the appendage. Tissue ingrowth into the tissue engaging surfaces retains the clamp in place on the appendage.

An automated machine for handling and embedding tissue samples contained on microtome sectionable supports. The machine includes an input member configured to hold a plurality of the microtome sectionable supports prior to a tissue embedding operation. An output member is configured to hold a plurality of the microtome sectionable supports after the tissue embedding operation. A cooling unit is configured to hold at least one of the microtome sectionable supports during the tissue embedding operation. A motorized carrier assembly is mounted for movement and configured to hold at least one of the microtome sectionable supports. The carrier assembly moves the support from the input member to the cooling unit and, finally, to the output member. A dispensing device dispenses an embedding material onto the microtome sectionable support and at least one tissue sample carried by the microtome sectionable support during the embedding operation.

Method for automated processing and embedding of tissue samples

A method of staging a tissue sample cassette, including a cassette body and a lid, from an upper position in a frame used during a tissue embedding process to a lower position in the frame. The method comprises coupling the cassette with the frame such that the cassette is in the upper position and positively stopped at the upper position by first structure on a wall of the frame. The cassette is moved relative to the frame to the lower position by selectively engaging the cassette with a staging mechanism. An external force is applied to the cassette with the staging mechanism in a direction to move the cassette from the upper position toward the lower position. The cassette is retained in the lower position using second structure on the wall of the frame, such that the cassette is exposed for embedding the cassette in an embedding medium and subsequently slicing the tissue sample embedded in the embedding medium.

Method of staging a tissue sample cassette

An electrosurgical end effector for ablating tissue is provided that comprises at least one electrically-conductive ablation member adapted to be connected to a source of RF energy, with the ablation member having a tissue engaging surface and an internal fluid passageway. Preferably, the end effector includes two electrically conductive ablation members that are electrically isolated from one another.

Ablation device with cooled electrodes and methods of use

Growing community of inventors

Loveland, OH, United States of America

Warren P Williamson, Iv