University of Memphis Research Foundation

Wright Medical Technology, Inc.

Lifecell Corporation

Warren Oliver Haggard

Scott P Noel

Joel D Bumgardner

Olaf H Schulz

Michael Earl Kaufman

Jack Eldon Parr

Linda Morris

Robyn J Overby

Ann V Burgess

Benjamin T Reves

Donald A Randolph

Herbert Daniel Beniker

Donald W Petersen

David J McQuillan

Michael Vincent

Cary P Hagan

Lawrence E Boerboom

Jessica Amber Jennings

Kelly C Richelsoph

James Keaton Smith

Ashley C Parker

David J Mcquillan

Stephen A Livesey

The invention provides compositions featuring chitosan and methods for using such compositions for the local delivery of biologically active agents to an open fracture, complex wound or other site of infection. Advantageously, the degradation and drug elution profiles of the chitosan compositions can be tailored to the needs of particular patients at the point of care (e.g., in a surgical suite, clinic, physician's office, or other clinical setting).

Compositions and methods for delivering an agent to a wound

The invention provides improved methods for generating biodegradable chitosan compositions, and therapeutic methods of using such compositions to deliver therapeutic agents.

Methods for producing a biodegradable chitosan composition and uses thereof

This invention provides a rapidly degrading composition for local delivery of a medicament, such as, an antibiotic. Additionally, this invention provides a method that can be used on the battlefield to deliver antibiotics as a preliminary treatment through the use of a rapidly degrading composition.

Local delivery method and composition

The invention includes a synthetic bone substitute material suitable for use as a replacement for cancellous bone in a bone graft composition, the material comprising a reticulated framework of interconnecting bioceramic struts defining an interconnecting interstitial void volume, and a solid non-porous composition substantially filling the interstitial void volume and in intimate contact with the reticulated framework, the pore-filling composition comprising calcium sulfate. Calcium triphosphate is a preferred bioceramic material for the reticulated framework.

Synthetic, malleable bone graft substitute material

A bone graft substitute composition comprising calcium sulfate; a mixing solution selected from the group consisting of sterile water, sodium chloride, phosphate buffered saline, potassium chloride, and sodium sulfate; and a plasticizing substance selected from the group consisting of carboxymethylcellulose, polyvinyl alcohol, methycellulose, and hydroxypropyl methylcellulose.

Bone graft substitute composition

Synthetic bone substitute material

A composite is disclosed having a controlled rate of dissolution. The composite includes (a) a first region that includes a first composition that includes calcium sulfate, the first region exhibiting a first rate of dissolution; and (b) a second region that includes a second composition that includes calcium sulfate, the second region exhibiting a second rate of dissolution, the first rate of dissolution being different from the second rate of dissolution.

Controlled release composite

A composite is disclosed having a controlled rate of dissolution. The composite includes (a) a first region that includes a first composition that includes calcium sulfate, the first region exhibiting a first rate of dissolution; and (b) a second region that includes a second composition that includes calcium sulfate, the second region exhibiting a second rate of dissolution, the first rate of dissolution being different from the second rate of dissolution

Growing community of inventors

Bartlett, TN, United States of America

Warren Oliver Haggard