Duke University

Spr Therapeutics, Inc.

Case Western Reserve University

Cardiac Pacemakers, Inc.

Boston Scientific Corporation

Teledyne Scientific and Imaging, LLC

Ndi Medical, LLC

Neurocon Aps

Warren M Grill

Joseph W Boggs, Ii

Maria E Bennett

John Chae

David T Brocker

Alan D Dorval, Ii

Kenneth J Gustafson

Christopher L Langdale

James A Hokanson

Tianhe Zhang

Amorn Wongsarnpigoon

Merrill J Birdno

Juan Gabriel Hincapie Ordonez

Graham Harold Creasey

Paul B Yoo

Brian Jeffrey Wenzel

Cameron C McIntyre

Kathryn W Stager

Rosemary H Zang

Ii Boggs Joseph W

Kevin L Kilgore

John T Mortimer

Robert Strother

John R Gilbert

Bryan Howell

Isaac Cassar

Nathan Titus

Alan D Dorval

Matthew A Schiefer

Shivanand Lad

Stephen Simons

Saso Jezernik

Thomas Sinkjaer

Jiangying Zhou

Mark A Peot

Dennis Turner

Nikki Pelot

Timothy Hoer

Alexander R Kent

Niccolo Terrando

William Huffman

Nico J M Rijkhoff

Merril J Birdno

John Gilbert

Merill J Birdno

Merrill Birdno

Embodiments of the present invention provide systems and methods for the treatment of pain through activation of select neural fibers. The neural fibers may comprise one or more afferent neural fibers and/or one or more efferent neural fibers. If afferent fibers are stimulated, alone or in combination with efferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate afferent pathways in a manner approximating natural afferent activity. The afferent fibers may be associated with primary receptors of muscle spindles, golgi tendon organs, secondary receptors of muscle spindles, joint receptors, touch receptors, and other types of mechanoreceptors and/or proprioceptors. If efferent fibers are stimulated, alone or in combination with afferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate intrafusal and/or extrafusal muscle fibers, which results in an indirect activation of afferent fibers associated therewith.

Systems and methods for the treatment of pain through neural fiber stimulation

The present disclosure provides a device for state-dependent pudendal nerve stimulation for bladder control in a subject and methods of making and using the same.

State-dependent pudendal nerve stimulation for bladder control

The present invention relates to a neuromodulation apparatus and methods of using the neuromodulation apparatus for treating bladder dysfunction.

State-dependent peripheral neuromodulation to treat bladder dysfunction

Systems and methods for determining optimal temporal patterns of neural stimulation are disclosed. According to an aspect, a method includes selecting a temporal pattern for neural stimulation. The method also includes determining a mutation type for altering a pattern of pulses of the temporal pattern. The method also includes identifying a location within the pattern of pulses of the temporal pattern to alter based on the determined mutation type. The method further includes altering the pattern of pulses of the temporal pattern based on the identified location and mutation type for application of the altered temporal pattern to a subject.

Systems and methods for determining optimal temporal patterns of neural stimulation

This present disclosure provides systems and methods relating to neuromodulation. In particular, the present disclosure provides systems and methods for identifying optimized temporal patterns of spinal cord simulation (SCS) for minimizing variability in patient responses to SCS. The systems and methods of neuromodulation disclosed herein facilitate the treatment of neuropathic pain associated with various disease states and clinical indications.

Systems and methods for minimizing response variability of spinal cord stimulation

Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant) pulse patterns or trains that embody features of the invention provide a lower average frequency.

Non-regular electrical stimulation patterns for treating neurological disorders

Embodiments of the present invention provide systems and methods for the treatment of pain through activation of select neural fibers. The neural fibers may comprise one or more afferent neural fibers and/or one or more efferent neural fibers. If afferent fibers are stimulated, alone or in combination with efferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate afferent pathways in a manner approximating natural afferent activity. The afferent fibers may be associated with primary receptors of muscle spindles, golgi tendon organs, secondary, receptors of muscle spindles, joint receptors, touch receptors, and other types of mechanoreceptors and/or proprioceptors. If efferent fibers are stimulated, alone or in combination with afferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate intrafusal and/or extrafusal muscle fibers, which results in an indirect activation of afferent fibers associated therewith.

The present disclosure provides systems and methods for targeted nerve stimulation. In particular, the present disclosure provides systems and methods for determining the location of electrode placement providing the most therapeutic benefit for a particular subject. The various embodiments disclosed herein include methods for identifying a target nerve having the strongest representation and/or the strongest subject perception associated with a peripheral nerve in a patient-specific manner.

Systems and methods for targeted sacral nerve stimulation

It has been discovered that pain felt in a given region of the body can be treated by stimulating a peripheral nerve at a therapeutically effective distance from the region where pain is felt to generate a comfortable sensation (i.e., paresthesia) overlapping the regions of pain. A method has been developed to reduce pain in a painful region following limb joint replacement by stimulating a peripheral nerve innervating the painful region with an electrode inserted into tissue and spaced from the peripheral nerve. This method may be used to help alleviate postoperative pain in patients following total knee arthroplasty surgery or other limb joint replacement surgeries.

System and method for treatment of pain related to limb joint replacement surgery

Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant) pulse patterns or trains that embody features of the invention provide a lower average frequency. The systems and methods for stimulation of neurological tissue may be used to increase the efficacy of treatment in patients with Parkinson's Disease.

Non-regular electrical stimulation patterns for improved efficiency in treating Parkinson's disease

A system for delivering electrical pulse stimulation to a subject includes a remote control device configured to at least intermittently transmit temporal pulse pattern programming and a stimulation device comprising a control interface, at least one electrode in electrical communication with the control interface, and an input device in at least intermittent communication with the remote control device to receive the temporal pulse pattern programming. The stimulation device is configured to deliver electrical pulse stimulation to a subject via the at least one electrode according to the temporal pulse pattern programming.

Systems and methods for spinal cord stimulation

Non-regular electrical stimulation patterns designed with a cost function for treating neurological disorders

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Chapel Hill, NC, United States of America

Warren M Grill