Columbia University

Johns Hopkins University

Warren L Grayson

Gordana Vunjak-Novakovic

Keith Yeager

Colin Cook

Jennifer H Elisseeff

Donald O Freytes

Sarindr Bhumiratana

Nina Tandon

Amandine Godier-Furnémont

George Eng

Robert Maidhof

Ben Hung

Ethan Nyberg

Qun Wan

Tram Nguyen

Devices and methods for delivering oxygen and other therapeutic gases to a target, such as a tissue, a tissue-engineered construct, and a wound, in a controlled and sustained manner are disclosed.

Controlled outgassing of hyperbarically loaded materials for the delivery of oxygen and other therapeutic gases in biomedical applications

An extracellular matrix (ECM) mixture and ECM scaffolds made with same are disclosed. The ECM mixture can comprise from about 5% to about 85% by weight of ECM material and from about 15% to about 95% by weight of a polymer material, such as, but not limited to, a biodegradable polyester. The presently disclosed anatomically-shaped porous ECM scaffolds can be formed, for example, using a three-dimensional (3D) printing process, an injection molding process, or any other process.

Extracellular matrix (ECM) mixture and ECM scaffolds made with same

Controlled outgassing of hyberbarically loaded materials for the delivery of oxygen and other therapeutic gases in biomedical applications

An anatomically-shaped, human bone graft may be cultivated ex vivo using a bioreactor capable of perfusing large complex porous scaffolds. Scaffolds derived from image-based modeling of a target are seeded with human mesenchymal stem cells and cultivated. A bioreactor configured to house complex three-dimensional scaffold geometries provides controlled flow for perfusion of the cells. Dense uniform cellular growth can be attained throughout the entire scaffold as a result of the medium perfusion. In an embodiment, the bioreactor has a mold into which perfusion medium is pumped under pressure and multiple ports through which the medium exits the mold.

Method of making a personalized bone graft

Tissue engineering system for making personalized bone graft

Disclosed are bioreactor devices, systems and methods. A bioreactor system can include one or more bioreactor modules that can be individually controllable and identifiable. A bioreactor module can be connected to one or more functional modules such as a pump module, a stimulation signal generation module, a motor module, a mechanical transmission module, a gas exchange module, a temperature module, a humidity module and/or a COmodule, among others. The bioreactor and functional modules can include standard or universal connectors to facilitate connection and movement of modules. The bioreactor system can be controlled and/or monitored by a controller that can individually identify and control each connected module and that can be adapted to collect signal data from sensors embedded in any of the modules.

Bioreactor, devices, systems and methods

Growing community of inventors

Reisterstown, MD, United States of America

Warren L Grayson