Glaxo Inc.

Warren J Jochem

Robert A Casper

Michael L McCartney

Alan F Parr

A medical capsule device for releasing a substance at a defined location in the gastrointestinal tract. The device has a capsule body defining one or more apertures in the circumferential wall thereof and a sleeve valve rotatably positioned therein having one or more corresponding apertures in the circumferential wall thereof. The sleeve valve comprises a coil and electrically connected heatable resistor which are operatively associated with an actuator member formed of a shape memory alloy responsive to heat and which will move from a non-heated first shape to a heated second shape. Actuator stop means are provided in the capsule body for being engaged by the actuator member during movement from the non-heated first shape to the heated second shape so that the actuator member movement will serve to rotate the sleeve valve to an open position.

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Cary, NC, United States of America

Warren J Jochem