Mallinckrodt Medical, Inc.

Warren E Hall

David H White

Youlin Lin

Mills T Kneller

Rebecca A Wallace

David M Wong

Thomas J Dunn

Mark E Bosworth

Richard G Johnson

The use of reverse osmosis as an alternative or substitute method for the purification of a crude diagnostic agent. X-ray contrast agent, magnetic resonance imaging agent, or radiopharmaceuticals are purified by passing through a cross-linked reverse osmosis membrane.

Purification of X-ray contrast agent, magnetic resonance imaging agent,

The use of reverse osmosis as an alternative or substitute method for the purification of a crude diagnostic agent. In the purification process a crude Ioversol solution is contacted with a cross-linked membrane under pressure, forcing the low molecular weight impurities within the crude Ioversol solution through the membrane pores and retaining Ioversol molecules.

Purification of crude Ioversol using reverse osmosis

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St. Louis, MO, United States of America

Warren E Hall