Smithkline Beecham Corporation

Ward Whitlock Smith, Jr

Sherin Salaheldin Abdel-Meguid

Cheryl Ann Janson

Christine Marie Debouck

Jeffrey S Culp

Xiayang Qiu

Susan S Hoog

Renee Louise DesJarlais

Baoguang Zhao

A novel cathepsin K crystalline stucture is identified. Also disclosed are methods of identifying inhibitors of this protease and methods of inhibiting cathepsin K using inhibitors with certain structural, physical and spatial characteristics.

Method of inhibiting cathepsin K

Novel herpes viral protease crystalline structures are identified which have an active site formed by the three amino acids Ser, His and His. Also disclosed are methods of identifying inhibitors of these proteases and/or active sites.

Proteases compositions capable of binding to said site, and methods of

Proteases, compositions capable of binding to said site, and methods of

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Bryn Mawr, PA, United States of America

Ward Whitlock Smith, Jr