Neurocrine Biosciences, Inc.

Cidara Therapeutics, Inc.

Wanlong Jiang

Martin W Rowbottom

Warren Stanfield Wade

Mi Chen

Timothy Richard Coon

Neil Ashweek

Todd Ewing

Yun-Fei Zhu

Graham Beaton

Richard B Lowe

Allen Borchardt

Nicole Harriott

Liren Zhao

Willy Moree

Nicole Smith

Jinghua Yu

Thanh To Lam

Quyen-Quyen Thuy Do

Thomas P Brady

Daniel C Bensen

Zhi-Yong Chen

Leslie W Tari

Jason Cole

James M Balkovec

Alain Noncovich

Simon Doehrmann

Martin Rowbottom

Richard Lowe

Warren Wade

Compositions and methods for the treatment of viral infections include conjugates containing inhibitors of viral neuraminidase (e.g., zanamivir, peramivir, or analogs thereof) linked to an Fc monomer, an Fc domain, and Fc-binding peptide, an albumin protein, or albumin-binding peptide. In particular, conjugates can be used in the treatment of viral infections (e.g., influenza viral infections).

Compositions and methods for the treatment of viral infections

GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein R, R, R, R, R, R, and A are as defined herein, including stereoisomers, esters, solvates and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.

Gonadotropin-releasing hormone receptor antagonists and methods relating thereto

GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein R, R, R, R, R, R, and A are as defined herein, including stereoisomers, esters, solvates, and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.

GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure, wherein R, R, R, R, R, R, and A are as defined herein, including stereoisomers, esters, solvates and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof. 

Growing community of inventors

San Diego, CA, United States of America

Wanlong Jiang