University of Utah Research Foundation

Wanjian Jia

Glenn D Prestwich

Siam Oottamasathien

Won Yong Lee

Lindsi McCoard

Joseph Cappello

Hamidreza Ghandehari

Mark Martin Jensen

Lindsi M Roundy

Siam Oottamasathien, Viii

Described herein are in situ gelling compositions. The compositions include an anti-inflammatory polysaccharide and a gelling polymer, wherein the composition is a liquid prior to administration to a subject but converts to a gel upon administration to the subject. The compositions described herein have numerous applications with respect to the local treatment (reduction or prevention) of inflammation and/or tissue damage.

In situ gelling compositions for the treatment or prevention of inflammation and tissue damage

Described herein are pharmaceutical compositions composed of low molecular weight sulfated hyaluronan.

Pharmaceutical compositions composed of low molecular weight sulfated hyaluronan

Described herein are methods for treating or preventing urological inflammation in a subject comprising administering to the subject an effective amount of a compound comprising a. a modified hyaluronan or a pharmaceutically acceptable salt or ester thereof, wherein said hyaluronan or its pharmaceutically acceptable salt or ester comprises at least one sulfate group and at least one primary C-6 hydroxyl position of an N-acetyl-glucosamine residue comprising an alkyl group or fluoroalkyl group; b. a partially or fully sulfated hyaluronan or the pharmaceutically acceptable salt or ester thereof, or a combination thereof.

Methods for treating or preventing urological inflammation

Described herein are methods for treating interstitial cystitis in a subject comprising administering to the subject an effective amount of a compound which is

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Salt Lake City, UT, United States of America

Wanjian Jia