Tasly Pharmaceutical Group Co., Ltd.

Wangyi Zhou

Xiaohui Ma

Yonghong Zhu

Shuiping Zhou

Min Han

Guocheng Wang

He Sun

Jing Wang

Yanyong Liu

Lanlan Zhang

Yuanpeng Jin

Lulu Yan

Yanchuan Li

Xuejun Luo

Disclosed is an application of substituted cinnamamide derivatives in the preparation of anti-anxiety medications, the substituted cinnammide derivatives are compounds having the structure of formula (I) or pharmaceutically acceptable salts thereof, wherein, Ris &#x2014;H, &#x2014;OH, &#x2014;F, &#x2014;Cl, &#x2014;Br, &#x2014;I, &#x2014;OCH, &#x2014;OCF, &#x2014;OCHF, &#x2014;OCHF, &#x2014;CF, &#x2014;CHF, &#x2014;CHF, &#x2014;CH, &#x2014;CHCH, &#x2014;CFCH, &#x2014;CN, &#x2014;NO, &#x2014;NHor &#x2014;COOR; Ris H, C-Clinear alkyl, C-Cbranched alkyl, C-Ccyclic alkyl, C-Chydroxyalkyl or a N-substituted piperazine-derived group; or Ris a group forming with adjacent Y a tetrahydropyrrolyl group, a piperidyl group or a cyclohexanimido group. 

Application of substituted cinnamamide derivatives in preparation of anti-anxiety medication

The present invention relates to substituted cinnamamide derivatives, the method for preparing thereof and the use thereof. Each of said derivatives has a structure of formula (I). The method for preparing the substituted cinnamamides and their derivatives of the present invention is also disclosed. Substituted piperonal derivatives are selected as starting materials to prepare the substituted cinnamamide derivatives of the present invention by Wittig reaction and acid-amine condensation reaction. Further, a use of the present compounds in preventing and treating depressive-type mental diseases is disclosed. 

Substituted cinnamamide derivative, preparation method and use thereof

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Tianjin, China

Wangyi Zhou