Tianjin Fusogen Biotech Co., Ltd.

Wangni Tian

Genfa Zhou

A fusion inhibitor used to treat HIV infection, has an amino acid sequence as follows:X-SWETWEREIENYTKQIYKILEESQEQQDRNEKDLLE-Z,wherein X is either an amino group or -X1-X2, wherein X1 is an imino group, and X2 is either an acetyl group, a hydrophobic group, or a macromolecular carrier group; Z is a carboxyl group or -Z1-Z2, wherein Z1 is a carbonyl group, and Z2 is either an amino group, a tert-butyloxycarbonyl group, a hydrophobic group, or a macromolecular carrier group. This inhibitor has strong inhibitory activity against HIV infection.

Pharmaceutical used for treating HIV infection, the composition and uses thereof

A pharmaceutical being used for treating HIV infection is provided which has the following peptide sequence: X-SWETWEREIENYTKQIYKILEESQQDRN-EKDRNEKDLLE-Z, where S is Serine, W is Trytophan, E is Glutamate, T is Threonine, R is Argine, I is Isoleucine, N is Asparagine, Y is Tyrosine, K is Lysine, Q is Glutamine, L is Leucine, D is Aspartic acid, X is amino group, acetyl-hydrophobic group, or macromolecule carrier group, Z is carboxyl group, amino group, amido group, tert-nutyloxycarbonyl group, hydrophobic group, or macromolecule carrier group. The drug inhibits strongly the infection of HIV.

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Jilin, China

Wangni Tian