Korea Research Institute of Bioscience and Biotechnology

Sungkyunkwan University

Korea Institute of Oriental Medicine

Wan Yi Li

Hang Jin

Kyung Seop Ahn

Sei Ryang Oh

Sang Ho Choi

Sang Woo Lee

Hyung Won Ryu

Sang-Woo Lee

Hyeong Kyu Lee

Sei-Ryang Oh

Ok-Kyoung Kwon

Doo Young Kim

Jung Hee Kim

Joong Ku Lee

In Sik Shin

Ok Kyoung Kwon

Seung Hyung Kim

Hyouk Joung

Joongku Lee

Choon Gon Jang

Mee-Young Lee

Hwa-Young Son

Kyoung-youl Lee

Seung Hwan Kwon

The present invention relates to a composition for suppressing chronic obstructive pulmonary disease (COPD) comprising aextract, a fraction thereof, or a compound isolated therefrom and, more particularly, to a pharmaceutical composition for preventing or treating COPD comprising aextract, a fraction thereof, or a compound isolated therefrom; a food composition for preventing or improving COPD, and the compound isolated therefrom. The composition comprising aextract, a fraction thereof, or a compound isolated therefrom, according to the present invention, is not toxic, suppresses the invasion of inflammatory cells into the bronchial tube of a COPD-induced animal model, and effectively suppresses the expression of CXCL-1, TNF-&#x3b1;, or MIP-2. In addition, due to the use of a safety-proven herbal drug as a raw material, the composition of the present invention can resolve various side-effects of existing therapeutic agents for COPD, chronic obstructive bronchitis, chronic bronchiolitis, emphysema, multiple sclerosis, and acute and chronic inflammation, and thus can be effectively used as a composition for preventing, treating and remedying COPD.

Pharmaceutical composition comprisingextract, fraction of same or compound separated from same for preventing or treating chronic obstructive pulmonary disease (COPD)

The present invention relates to a pharmaceutical composition and a food composition containingHook. extract or a fraction thereof as an active ingredient for preventing, treating or ameliorating neuroinflammation or neuro-degenerative diseases. TheHook. extract or a fraction thereof according to the present invention is derived from a natural product which has been in use as a natural medicinal ingredient, and as such, has no side effects and inhibits expression of NO, PGE, iNOS and/or COX-2 genes or protein, which are factors associated with inflammation, and is additionally superbly effective for increasing and improving memory and the ability to learn, and thus can be beneficially used to prevent or treat neuroinflammation or neuro-degenerative diseases.

Method for treating neuroinflammation with a pharmaceutical composition containinghook. extract or fraction thereof as active ingredient

A pharmaceutical composition for the prevention and treatment of inflammatory disease or asthma comprising the extract ofas an active ingredient. The extract ofof the present invention inhibited the increase of eosinophils in bronchoalveolar lavage fluid of the ovalbumin induced asthma animal model, had the activity of inhibiting the secretions of immunoglobulin and chemokine (Eotaxin) in bronchoalveolar lavage fluid and blood, and inhibited the secretions of NO and TNF-&#x3b1; in macrophages. Therefore, the extract ofof the present invention can be effectively used as an active ingredient of a pharmaceutical composition for the prevention and treatment of inflammatory disease or asthma, and of a health functional food for the prevention and improvement of inflammatory disease or asthma.

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Growing community of inventors

Yunnan, China

Wan Yi Li