Curiox Biosystems Pte Ltd.

Wan Yee Leong

Namyong Kim

Eng Seng Lim

Siah Chong Cheong

Kong Leong Cheng

Hanwen Melvin Lye

Zhong Wang

Mark S Phong

The present invention provides an apparatus for conducting biological assays which employs 'virtual wells' in lieu of the physical wells of conventional array plates. Also provided are methods of processing a sample and/or culturing cells using the apparatus and systems described herein. In some embodiments, the apparatus includes a first structure having a sheet layer with a plurality of discrete through holes; and a second structure coupled to the first structure, the second structure including a base layer. At least a portion of a first surface of the sheet layer of the first structure is exposed from the second structure, and a second surface of the sheet layer, opposite to the first surface of the sheet layer, is embedded in the base layer of the second structure adjacent the first surface of the base layer.

High throughput miniaturized assay system and methods

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Boston, MA, United States of America

Wan Yee Leong