Intelligent Synthetic Biology Center

Korea Advanced Institute of Science and Technology

Korea Research Institute of Bioscience and Biotechnology

Wan Taek Im

Sun Chang Kim

Woo Hyun Kim

Suk Chae Jung

Chang Hao Cui

Gil Tsu Choi

Sun-Chang Kim

Yeon Hwa Lee

Myung Keun Park

Hyung Gwan Lee

Dong Shan An

Soo Hwan Lim

Sung Taik Lee

Won Il Jeong

Song Gun Kim

Won Ii Jeong

Yeon Lee

Ju Yeon Jung

Provided are a pharmaceutical composition for preventing or treating cervical cancer including gypenoside LXXV or a pharmaceutically acceptable salt thereof as an active ingredient, a method of preventing or treating cervical cancer including administering the pharmaceutical composition to a subject excluding humans, a health functional food composition for preventing or improving cervical cancer including gypenoside LXXV as an active ingredient, and a feed composition for preventing or improving cervical cancer including gypenoside LXXV as an active ingredient.

Composition for preventing or treating cervical cancer including gypenoside LXXV

The present invention relates to a uridine diphosphate (UDP)-glycosyltransferase protein which has glycosylation activity for a hydroxyl group at the C-20 position of a protopanaxadiol (PPD)- or protopanaxatriol (PPT)-type ginsenoside, and a method for glycosylation of UDP using the same.

Method for glycosylation of ginsenoside using a glycosyltransferase derived from panax ginseng

Provided are a method of producing minor ginsenosides using a ginsenoside glycosidase protein derived from asp. () microorganism, and a composition including the protein for conversion into minor ginsenosides. The ginsenoside glycosidase exhibits very excellent activity of specifically hydrolyzing a sugar at the C-6 position of ginsenoside to convert the ginsenoside into in-vivo absorbable minor ginsenoside, thereby being very usefully applied to mass-production of ginsenoside.

Method for producing a minor ginsenoside using a ginsenoside glycosidase

The present invention relates to a novel uridine diphosphate (UDP)-glycosyltransferase, and particularly to a novel UDP-glycosyltransferase derived fromand use thereof, a method for preparing glycosylated ginsenoside by converting protopanaxadiol (PPD)-type ginsenoside using the UDP-glycosyltransferase, a composition for converting the PPD-type ginsenoside into glycosylated ginsenoside, comprising the UDP-glycosyltransferase, a transformant or a culture thereof as active ingredients, a method for enhancing the expression of the UDP-glycosyltransferase using MeJA (methyl jasmonate), and a composition for enhancing the expression of the UDP-glycosyltransferase, which comprises MeJA as an active ingredient.

UDP-glycosyltransferase derived from ginseng and use thereof

The present invention relates to a novel ginsenoside glycosidase protein derived from the genus, the protein having an activity of converting protopanaxadiol (PPD)-type saponins into highly active substances, which can be absorbed inside the body, by selective hydrolysis of a particular bond of ginsenoside. More specifically, the present invention relates to an amino acid sequence of the protein, a nucleic acid sequence encoding the protein, a recombinant vector comprising the nucleic acid sequence, and a transformant transformed with the vector, and a method for producing ginsenoside glycosidase derived from the genusby culturing the transformant, a method for converting PPD-type major saponins into the minor saponin forms using the protein, and a composition for converting PPD-type saponins into soluble saponins, comprising the protein as an active component.

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Daejeon, South Korea

Wan Taek Im