Kt&g Corporation

Chemtech Research Incorporation

Other

Korea Advanced Institute of Science and Technology

Hanmi Pharm. Co., Ltd.

Hlb Pharmaceutical Co., Ltd

Wan Joo Kim

Gwan Sun Lee

Jae Won Choi

Tae Hee Ha

Sang Hwi Lee

Jung Young Kim

Tae Suk Lee

Young Ho Moon

Cheol Hee Lee

Kwang Ok Lee

Nam Du Kim

Chang Hyun Yoo

Dong Jo Chang

Moon H Lee

Jung Ae Shin

Ki Byung Chai

Dong Hoo Kim

Soon Ok Kim

Jung Min Jang

Mijung Kim

Dooyong Jeong

Mi Jung Kim

So Kyoung Joo

Hyun Suk An

Jong Yek Park

Myung Hwa Kim

Gun Bong Lee

Eun Young Yoon

The present invention relates to a method for preparing biodegradable microspheres using a single-phase mixed solution containing water, alcohol, and dichloromethane. Provided is a method for preparing a biodegradable microsphere having a uniform drug loading efficiency by preparing and using a single-phase mixed solution in which no phase separation occurs without using a thickener and a surfactant. The preparation method of the present invention has the feature of keeping the content of a loaded drug uniform until a final biodegradable microsphere is prepared, by using a single-phase mixed solution in which no phase separation by a solvent occurs in the preparation process. Thus, the preparation method of the present invention is remarkably useful for the preparation of biodegradable microspheres.

Method for preparing biodegradable microspheres using stabilized single-phase mixed solution

The present invention relates to tricyclic colchicine derivatives represented by the formulas (I) or (II), pharmaceutically acceptable salts thereof, and a method for providing an immuno-suppressive or immuno-modulating effect, an anti-proliferative effect, an anti-inflammatory effect or a method for treating cancer comprising administering to a patient an effective amount of one or more colchicine derivatives: 

Tricyclic derivatives and their use

Colchicine derivatives represented by the formula (I) with a halogen or nitric ester group, or pharmaceutically acceptable salts thereof, are described. Pharmaceutical compositions containing the same as effective components are also described. The colchicine derivatives were found to have anticancer, anti-proliferous and immunosuppressive function. Methods for preparing the colchicines derivatives are also provided.

Alkaloid derivative and a pharmaceutical composition containing the same

Intermediates, process for preparing macrolide antibiotic agent therefrom

Process for preparing paclitaxel

A method for the preparation of 3-methylene cepham compounds which comprises reacting 3-halomethyl butenoate derivatives of thiazolinoazetidinone with an aqueous acid solution in a mixed organic solvent.

Method of preparation of 3-methylene cepham compounds

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Seoul, South Korea

Wan Joo Kim