Deutsche Gold- Und Silber-scheideanstalt Vormals Roessler

Walter VONBebenburg

Heribert Offermanns

Karl-Heinz Gluzek

Friedrich Asinger

Compounds are prepared having the formula: ##STR1## where R.sub.1 is alkyl of 1 to 6 carbon atoms or phenyl and R.sub.2 is hydrogen or halogen and tautomeric form and pharmacologically acceptable salts thereof. The compounds have sedative, psychosedative, anxiolytic and spasmolytic properties and in some cases antiphlogistic properties.

5-Aryl-pyrido-(b-6,7)-1,4-diazaepine with an additional fused

There are produced 6-aza-3H-1,4-benzodiazepines and 6-aza-1,2-dihydro-3H-1,4-benzodiazepines of the formula: ##STR1## wherein R.sub.1 is the group --NR.sub.a R.sub.b or --NR.sub.a R.sub.b R.sub.c halide and R.sub.a and R.sub.b are the same or different and are hydrogen, alkyl groups of 1 to 6 carbon atoms, or alkyl groups of 1 to 6 carbon atoms substituted by hydroxy, phenyl or a carboxy group, and R.sub.c can be as defined for R.sub.a and R.sub.b except it cannot be hydrogen and wherein the group --NR.sub.a R.sub.b also can be a saturated closed 5, 6 or 7 membered ring which in a given case has a further oxygen atom or nitrogen atom or contains a nitrogen atom substituted with an alkyl group having 1 to 4 carbon atoms;

6-Aza-3H-1,4-benzodiazepines

The D-form of an optically active protected penicillamine is prepared by treating a solution of D,L protected penicillamine of the formula: ##EQU1## wherein Ac is formyl, and R.sub.1 and R.sub.2 are both methyl or are joined together to form the pentamethylene group.

Growing community of inventors

Buchschlag, Germany

Walter VONBebenburg