Iowa State University Research Foundation Inc

Zoetis Services LLC

Walter Valdez

Jay Gregory Calvert

John Morgan Hardham

James Richard Thompson

Qi Chen

Mira Ivanova Stoeva

Jianqiang Zhang

Phillip Gauger

Darin Madson

Meggan Bandrick

The present invention is directed to novel nucleotide and amino acid sequences of Porcine Epidemic Diarrhea Virus ('PEDV'), including novel genotypes thereof, all of which are useful in the preparation of vaccines for treating and preventing diseases in swine and other animals. Vaccines provided according to the practice of the invention are effective against multiple swine PEDV genotypes and isolates. Diagnostic and therapeutic polyclonal and monoclonal antibodies are also a feature of the present invention, as are infectious clones useful in the propagation of the virus and in the preparation of vaccines. Particularly important aspects of the invention include polynucleotide constructs that replicate in tissue culture and in host swine. The invention also provides for novel full length PEDV genomes that can replicate efficiently in host animals and tissue culture.

Porcine epidemic diarrhea virus strains and immunogenic compositions therefrom

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Parsippany, NJ, United States of America

Walter Valdez