Boehringer Ingelheim International Gmbh

Boehringer Ingelheim Pharma Gmbh & Co Kg

Boehringer Ingelheim Pharmaceuticals, Inc.

Boehringer Ingelheim Pharma Kg

Boehringer Ingelheim Zentrale

Walter Spevak

Armin Heckel

Gerald Juergen Roth

Rainer Walter

Martin Lenter

Rudolf Hauptmann

Gisela Schnapp

Frank Himmelsbach

Ingrid Maurer-Fogy

Christian Stratowa

Elinborg Ostermann

Andreas Zophel

Jacobus Van Meel

Konrad Heckl

Maria J Wiche-Castanon

Edeltraud Krystek

Georg Dahmann

Joerg Kley

Alexander Pautsch

Martin Steegmaier

Steffen Steurer

Andreas Schoop

Ulrike Tontsch-Grunt

Ulrike Weyer-Czernilofsky

Bernd Krist

Helmut Wittneben

Ulrich Reiser

Norbert Redemann

Anthony S Prokopowicz

Wolfgang Eberlein

Wolfgang Grell

Peter Ettmayer

Frank Hilberg

Peter Swetly

Gunther R Adolf

Jacobus C A Van Meel

Oliver Kraemer

Peter Sennhenn

Alastair L Parkes

Andreas Steffen

Gerd Bader

Anthony S Prokopowicz, Iii

Thomas Von Rueden

Jacobus Ca Van Meel

Maria J Castanon

Ewa Chlebowicz-Sledziewska

Andrzej Sledziewski

Gisela Schapp

6-Alkynylpyridines which are SMAC mimetics and are useful as medicaments for the treatment of diseases characterized by excessive or abnormal cell proliferation and associated conditions such as cancer. The following compounds are exemplary:

6-alkynylpyridines

The present invention relates to trisubstituted pyrimidines of formula (I) wherein

Pyrimidine derivatives

The present invention encompasses compounds of general formula (1) wherein R, M, Land Q are defined as in claim, which are suitable for the treatment of diseases characterized by excessive or anomalous cell proliferation, and the use thereof for preparing a pharmaceutical composition with the above-mentioned properties. 

Chemical compounds

The present invention relates to trisubstituted pyrimidines of formula (I) wherein0Rto Rare defined as in claim, which are suitable for the treatment of illnesses characterized by excessive or abnormal cell proliferation, the use thereof for preparing a pharmaceutical composition with the abovementioned properties, and processes for the preparation thereof.

The present invention relates to trisubstituted pyrimidines of formula (I) wherein0Rto Rare defined as in claim 1, which are suitable for the treatment of illnesses characterised by excessive or abnormal cell proliferation, the use thereof for preparing a pharmaceutical composition with the abovementioned properties, and processes for the preparation thereof.

Indolinones of general formula I which are inhibitors of cell proliferation, particularly of tumor cells, and inhibitors of protein kinases.

Substituted indolinones, preparation thereof and their use as pharmaceutical compositions

The present invention relates to new substituted indolinones of general formulawherein The above compounds of general formula I wherein Rdenotes a hydrogen atom, a C-alkyl group or a prodrug group have valuable pharmacological properties, particularly an inhibiting effect on various kinases, on viral cyclin and on receptor tyrosine kinases, and the other compounds of the above general formula I wherein Rdoes not represent a hydrogen atom, a C-alkyl group or a prodrug group are valuable intermediate products for the preparation of the abovementioned compounds.

Substituted indolines with an inhibitory effect on various kinases and complexes of CDKs

Substituted indolinones, their manufacture and their use as medicaments

Substituted indolines which inhibit receptor tyrosine kinases

This invention relates to a process for preparing human lysozyme and the human lysozyme protein itself.

Human lysozyme

The present invention relates to a method of preparing human Mn-superoxide dismutase (hMn-SOD) by genetic engineering, the DNA sequences which code for this enzyme, suitable vectors which contain these DNA sequences and host cells which can express these DNA sequences, and the enzyme hMn-SOD itself. Suggestions as to the use of this enzyme are also described.

Human manganese superoxide dismutase (hMn-SOD)

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Oberrohrbach, Austria

Walter Spevak