Novartis Ag

Johnson and Johnson Vision Care, Inc.

Alcon, Inc.

The Penn State Research Foundation

Ethicon, Gmbh

Ethicon, Inc. - USA

Walter R Laredo

Xuwei Jiang

Ali E Akinay

Douglas Schlueter

Stephen C Arnold

Frank Chang

Harry R Allcock

Troy Vernon Holland

David Jinkerson

Ryan DeSousa

Azaam Alli

Alireza Rezania

Kevin P McCabe

Charles Freeman

Vincent Nguyen

Susan Orr

James M Nelson

Kevin L Cooper

Howard Allen Ketelson

Joseph I Weinschenk, Iii

Hassan Chaouk

Aruna Nathan

Michael J Trezza, Ii

Roy H Hammerstedt

Zhigang Li

Stephen John Collins

Mark C Zimmerman

Rekha Rangarajan

Han Cui

Thomas A Callaghan

Chance Lehman

Jared D Bender

Chester A Crane

Robbyn Prange

Scott D Reeves

Maureen J Borgia

Ryan Desousa

Stephen S Schwartz

Christine R deDenus

Ankur S Kulshrestha

Douglas C Schlueter

Kevin P Mccabe

Joseph I Weinschenk

Iii Joseph I Weinschenk

Polymeric eye inserts are provided that may be dissolvable when placed in the cul-de-sac of the eye. These inserts may contain one or more polymers as well as a softener/plasticizer so that, when inserted into the eye, they may absorb tears, and dissolve and slowly release lubricant into the tear film to lubricate and protect the ocular surface for an extended duration of time. Increased retention time on the ocular surface for longer lasting relief may reduce dosing frequency and patient burden typically associated with topical drop usage. These polymeric eye inserts also may include one or more pharmaceutically active agents.

Dissolvable polymeric eye inserts and method of using same

Described herein are dimethyl acetal-containing UV-absorbing compounds and their uses in preparing UV-absorbing polyvinyl alcohol prepolymers suitable for producing UV-absorbing contact lenses capable of blocking ultra-violet ('UV') radiation and optionally (but preferably) violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation. This invention also provides a UV-absorbing polyvinyl alcohol prepolymer.

Water-soluble UV-absorbing compounds and uses thereof

Described herein are UV-absorbing vinylic monomers and their uses in preparing UV-absorbing contact lenses capable of blocking ultra-violet ('UV') radiation and violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation.

UV/visible-absorbing vinylic monomers and uses thereof

Intraocular lens materials are disclosed. They are soft and very deformable and have a high refractive index, and a high glistening resistance in fully hydrated state. They are particularly suitable for making wet-packed intraocular lenses (IOLs) which can be delivered through sub 2.0 mm incisions.

Wet-pack intraocular lens materials with high refractive index

Acrylate-acrylamide copolymers are disclosed. They are rigid and glassy in dry state at room temperature (from about 23&#xb0; C. to about 28&#xb0; C.), but are soft and very deformable and have a high refractive index, a high glistening resistance and a low aging-related surface light scattering in fully hydrated state. They are particularly suitable for making wet-packed intraocular lenses (IOLs) which can be delivered through sub 2.0 mm incisions.

Low-water content acrylate-acrylamide copolymers for ophthalmic devices

Hydrophobic acrylate-acrylamide copolymers for ophthalmic devices

Disclosed are improved ophthalmic and otorhinolaryngological device materials and devices formed therewith. The device materials are soft, high refractive index styrenic device materials that are used to form the ophthalmic or otorhinolaryngological devices, particularly ophthalmic implants (e.g., intraocular lenses).

Styrenic ophthalmic and otorhinolaryngological materials and devices formed therewith

High refractive index acrylic device materials with reduced glistenings are disclosed. The device materials are particularly suitable for use as ophthalmic or otorhhinolaryngological device materials and comprises a poly(phenyl ether)-containing monomer and/or a poly(phenyl ether)-containing cross-linking agent.

Soft acrylic materials with high refractive index and minimized glistening

The invention provides punctal plugs for the delivery of active agent to one or both of the tear fluid of the eye and to the nasolacrimal duct. The plugs of the invention have a body, a reservoir contained within the body, and optionally a collarette. The reservoir has at least one opening and contains a polymeric material and at least one active agent.

Punctal plugs for the delivery of active agents

Disclosed are soft, high refractive index, acrylic device materials. The materials contain a copolymeric additive for glistening resistance.

Ophthalmic and otorhinolaryngological device materials

Disclosed are low-tack, hydrophobic, high refractive index, acrylic materials. These materials, especially useful as intraocular lens materials, contain one or more aryl acrylic hydrophobic monomers as principal device-forming monomers, a tack-reducing block copolymer additive and a glistening-reducing additive. In addition to their use as intraocular lens materials, the present materials are also suitable for use in other implantable ophthalmic devices.

Low-tack, hydrophobic ophthalmic device materials

UV absorbing compounds that are effective in blocking UV and short-wavelength blue light are disclosed. The UV absorbing compounds are particularly suitable for use in intraocular lens materials.

UV-absorbers for ophthalmic lens materials

Disclosed are low-tack, hydrophobic, high refractive index, acrylic materials. These materials, especially useful as intraocular lens materials, contain one or more aryl acrylic hydrophobic monomers as principal device-forming monomers, a tack-reducing macromer additive and a glistening-reducing additive. In addition to their use as intraocular lens materials, the present materials are also suitable for use in other implantable ophthalmic devices.

Hydrophobic acrylic intraocular lens materials

Novel UV absorbing monomers are disclosed. The UV absorbers are particularly suitable for use in intraocular lens materials.

Growing community of inventors

Fort Worth, TX, United States of America

Walter R Laredo