Sandoz Gmbh

Walter Prikoszovich

Rainer Albert

Janos Pless

Wilfried Bauer

Zdenek Brich

Francois Cardinaux

Joachim Franz

Monika Mergler

The present invention provides a sugar derivative of a biologically active peptide, which derivative has a prolonged duration of action when compared to the non-sugar modified peptide, and contains at least on one of the amino acid units a sugar residue which is attached to an amino group thereof by a coupling other than a direct N-glycosidic bond, and additionally, when it is a condensation product of a carboxyl group containing sugar and a peptide with less than 8 amino acid units, by a coupling other than a direct amide bond.

Peptide derivatives

A product of an oligomer derived from glycolic acid and/or lactic acid, the oligomer having a molecular weight of from 500 to 10,000, the free carboxylic acid group of the oligomer being at least partially in the form of an amide with an amino acid or an ester with a sterol may be used as a matrix material for depot forms, containing pharmacologically active agents.

Oligomeric hydroxycarboxylic acid derivatives, their production and use

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Allschwil, Switzerland

Walter Prikoszovich