Novartis Ag

Novartis Pharma Gmbh

Walter Prikoszovich

Bernhard Wietfeld

Werner Heinz Pachinger

Bernhard Erb

Werner Pachinger

Gottfried Sedelmeier

Stuart J Mickel

Heribert Hellstern

Michael Foulkes

Hans Hirt

Frank Schäfer

The present invention provides a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren. Inter alia, the invention provides a process for the manufacture of a compound of the formula III, wherein R, R, R, Rand PG are as defined in the specification, or a salt thereof. The manufacture comprises (preferably consists of) reacting a compound of the formula I, with a reagent able to transform hydroxy into X where X is for example a leaving group.

Process for preparing renin inhibitors

Provided is a process for preparing cyclic somatostatin analogues and the linear intermediates used in this process.

Preparation of somatostatin peptides

The present invention relates to processes for preparing peptides and to intermediates involved in such processes, e.g. a process for preparing a compound of formula VIII wherein Rand Rare as defined herein.

Process for the synthesis of peptides containing a 4-hydroxy-proline substructure

Relating to organic compounds

Growing community of inventors

Schoenenbuch, Switzerland

Walter Prikoszovich