Henkel Ag & Company, Kgaa

Walter Ploeger

Rudolf Lehmann

Peter Wuelknitz

Hans-Juergen Klueppel

Karl-Heinz Schmid

Horst Rutzen

Manfred Biermann

Hinrich Moeller

Harald Schnegelberger

Karlheinz Hill

Franz Foerg

Franz Forg

Hans Laska

Plaque-inhibiting toothpaste comprising antibacterial biguanides

Oral-hygiene/dentifrice preparations which protect dental enamel

Aqueous homogeneous preparations containing 0.0025 to 0.1% by weight antimicrobial biguanide compounds, 0.005 to 0.2% by weight of an alkyl glycoside, 0.01 to 0.3% by weight of a water-insoluble aromatic oil, 0.01 to 0.3% by weight of a solubilizer from the group consisting of ethoxylated fatty acid glycerides, ethoxylated fatty acid sorbitan partial esters or fatty acid partial esters of glycerol or sorbitan ethoxylates show high activity despite the low concentration of antimicrobial biguanide compounds. The clear solubility is obtained without ethanol or with only very small contents of up to 15% by weight of ethanol. The preparations are particularly suitable as mouthwashes.

Antimicrobial flavored compositions having particular utility as mouth

Oral and dental hygiene preparations containing quaternary ammonium compounds of the formula ##STR1## wherein R.sup.1 is an n-alkyl group, preferably containing from 8 to 12 carbon atoms, R.sup.2 is hydrogen, a CH.sub.3 -group or a CH.sub.2 OH-group and R.sup.3 is a CH.sub.3 -group or a group of the formula --CH.sub.2 --CH(OH)--R.sup.2, A is an inorganic or organic acid anion and n is the basicity of the anion. The quaternary ammonium compounds of formula I can have a plaque inhibiting effect and show only slight antimicrobial activity. R.sup.1 is preferably an n-decyl group, R.sup.2 is hydrogen and R.sup.3 is a CH.sub.3 -group or a 2-hydroxyethyl group. The oral and dent al hygiene preparations also preferably contain fluorides and/or organophosphonates as the anion A.

Oral and dental hygiene preparations

Alkyl glycosides are used to greatly increase the microbicidal activity of biguanide compounds, such as chlorhexidine salts. The alkyl glycoside/biguanide agents have a particular utility in teeth cleaning preparations due to their improved microbicidal activity against gram-positive bacteria.

Alkyl glycosides as potentiating agents in antiseptic, disinfecting and

Oral and dental preparations containing as an active ingredient an anti-caries effective amount of a C.sub.2-4 alkoxylated trihydric to hexahydric C.sub.3-12 aliphatic polyol wherein at least one hydroxyl moiety is esterified with phosphoric acid, or a physiologically compatible water soluble salt thereof.

Anti-caries composition

Growing community of inventors

Hilden, Germany

Walter Ploeger