Degussa Aktiengesellschaft

Evonik Degussa Gmbh

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Degussa Gmbh

Degussa - Huls Ag

Evonik Operations Gmbh

Degussa Aktiengsellschaft

Degussa Ag Dusseldorf

Forschungszentrum Julich Gmbh

Walter Pfefferle

Mike Farwick

Brigitte Bathe

Thomas Hermann

Achim Marx

Michael Binder

Bettina Möckel

Klaus Huthmacher

Georg Thierbach

Lothar Eggeling

Bettina Moeckel

Caroline Kreutzer

Hermann Sahm

Bettina Mockel

Jörn Kalinowski

Dieter Greissinger

Mechthild Rieping

Stephan Hans

Bettina M&ouml;ckel

Alfred Pühler

Natalie Schischka

Miroslav Patek

Heinz Friedrich

Joern Kalinowski

Alfred Puehler

Alfred P&uuml;hler

Christian Rueckert

Anke Weissenborn

Michael Hartmann

J&ouml;rn Kalinowski

Matthias Moll

Alexander Moeller

IIona Walger

Ulrich Becker

Wolfgang Leuchtenberger

Hermann Lotter

Klaus-Erich Uffmann

Wolfgang Degener

Andreas Tauch

Madhavan Nampoothiri K

Caroline Kruetzer

Sahm Hermann

Alfred Puhler

Michael Schwarm

Nicole Dusch

Stefan Pelzer

Christine Bastuck

Bodo Speckmann

Petra Ziegler

Ines Ochrombel

Bernd Eikmanns

Yvonne Tilg

Wolf-Dieter Deckwer

Christian Rückert

Jennifer Brehme

Nicole Kennerknecht

Madhavan Nampoothiri

Caroline Reynen

Albert De Graaf

Michael Buchholz

Harald Voss

Bettina Hädrich

Bernhard Schilling

Bernd Bachmann

Klaus Hutchmacher

Holger Werning

Stefan Hans

Thoams Hermann

Monika Martens

Indra Schr&ouml;der

Mike Garwick

Oliver Kirchner

Klaus Erich Uffmann

Alfred Prof Pühler

Daniel Rey

Hermann Prof Sahm

A synbiotic preparation may include at least one probiotic strain and at least one amino acid or derivative thereof selected from glutamine, glutamic acid or salts thereof, conjugated glutamine, or oligopeptides of 2-10 amino acid units in length, wherein the amino acid units may be natural amino acids, and at least one amino acid unit being a glutamine or glutamic acid unit.

Synbiotic compositions

The invention relates to an isolated polynucleotide having a polynucleotide sequence which codes for the alr gene, and a host-vector system having a coryneform host bacterium in which the alr gene is present in attenuated form and a vector which carries at least the alr gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.

Coryneform host-vector systems comprising a chromosomal ALR gene which is attenuated or eliminated and methods of using

Nucleotide sequences encoding alanine racemase from coryneform

L-lysine-producing strains ofwith enhanced lysE gene (lysine export carrier gene), in which strains additional genes chosen from the group comprising the dapA gene (dihydrodipicolinate synthase gene), the lysC gene (aspartate kinase gene), the dapB gene (dihydrodipicolinate reductase gene) and the pyc gene, but especially the dapA gene and the lysC gene (aspartate kinase gene), are enhanced and, in particular, over-expressed, and a process for the preparation of L-lysine.

L-lysine-producing corynebacteria and process for the preparation of L-lysine

The invention relates to an isolated polynucleotide from coryneform bacteria containing at least one polynucleotide sequence selected from the group consisting of

Nucleotide sequence encoding the dapC gene and process for the production of L-lysine

The invention relates to alleles of the sigA gene from coryneform bacteria which code for sigma factors A and a process for the fermentative preparation of L-lysine using bacteria which contain these alleles.

Alleles of the sigA gene from coryneform bacteria

The invention relates to L-lysine-producing strains of corynebacteria with enhanced lysE gene (lysine export carrier gene), in which strains additional genes chosen from the group comprising the dapA gene (dihydrodipicolinate synthase gene), the lysC gene (aspartate kinase gene), the dapB gene (dihydrodipicolinate reductase gene) and the pyc gene, but especially the dapA gene and the lysC gene (aspartate kinase gene), are enhanced and, in particular, over-expressed, and to a process for the preparation of L-lysine.

Isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the lysR2 gene is present in attenuated form, and the use of the polynucleotide sequences as hybridization probes.

Nucleotide sequences for encoding of the lysR2-gene

The invention relates to sulfur-containing animal-feed additives produced from fermentation liquors, and to processes for their production.

Sulfur-containing animal-feed additives

The invention provides nucleotide sequences of the gpm gene which encode phosphoglycerate mutase, and fermentation processes for the preparation of amino acids, especially L-lysine, using corynebacteria wherein the gpm gene is amplified.

Nucleotide sequences encoding the gpm gene

Disclosed herein is an isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID NO:2, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID NO:2 c) polynucleotide which is complementary to the polynucleotides of a) and b) and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and processes for the fermentative preparation of L-amino acid with amplification of the zwa1 gene in the coryneform bacteria employed.

Process for the preparation of l-amino acids

The invention relates to an isolated polynucleotide fromhaving a polynucleotide sequence which encodes the sugar import protein K (msiK) gene, and a host-vector system having a coryneform host bacterium in which the msiK gene is present in enhanced form and a vector which carries at least the msiK gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.

Nucleotide sequences which code for the msiK gene

The invention relates to an isolated polynucleotide containing a polynucleotide sequence selected from the group comprising

Process for the preparation of L-amino acids via overexpression of the PTSH gene

The invention related to an isolated nucleic acid consisting of a fragment of the polynucleotide ofcitA gene or a fragment of the full complement of the polynucleotide of thecitA gene wherein said fragment is at least 30 consecutive nucleotide in length, and the vector and host cell harboring these nucleic acids.

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The invention relates to an isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of

Process for the preparation of L-amino acids by attenuating the mikE17 gene

Growing community of inventors

Halle, Germany

Walter Pfefferle