Ludwig Heumann & Co. Gmbh

Walter Otto Liebenow

Jaroslav Prikryl

Kurt H Ahrens

Ingomar Grafe

Edgar Fritschi

Hans Liedtke

Lothar Kisielowski

A simplified process for the preparation of basically substituted phenylacetonitriles, in particular of verapamil, is described. This process is carried out with fewer stages and higher yields than the known processes according to the state of the art.

Process for the preparation of basically substituted phenylacetonitriles

Quaternary 1,1-diphenyl-4-pyrrolidinium-2-butyne salts corresponding to the following general formula ##STR1## in which R represents methyl or ethyl and X is a chlorine or bromine atom, are described. These compounds are distinguished by improved spasmolytic and broncholytic activity.

Quaternary 1,1-diphenyl-4-pyrrolidinium-2-butyne salts, a process for

A compound selected from a 2,4-diamino-5-thiobenzylpyrimidine of the formula: ##STR1## in which R is selected from hydrogen, alkyl, lower alkoxy, and halogen and R' is alkyl; and pharmacologically acceptable acid addition salts thereof. These compounds have an anti-bacterial action and are sulphonamide potentiators.

2,4-Diamino-5-(4'-methylthio)benzylpyrimidenes, compounds, compositions

A process for the production of 2,4-diamino-5-(3',4',5'-trimethoxybenzyl)-pyrimidine by condensing trimethoxy benzaldehyde with a substituted propionitrile compound and reacting the condensation product obtained with guanidine, wherein a .beta.-akyl-(aryl-, benzyl-)-oxy-ethyleneoxy-propionitrile corresponding to the formula

Process for the production of

Bactericidal 4'-alkyldioxyalkylene-5-benzylpyrimidines, process for their production, and pharmaceutical compositions or formulations thereof, containing compounds of the general formula: ##SPC1## Wherein R.sub.1 is an alkyl group containing from 1 to 3 carbon atoms, R is an atom of hydrogen, an atom of halogen, or an alkyl or alkoxy group containing from 1 to 3 carbon atoms, and n is an integer of from 1 to 3, Exhibit excellent bactericidal activity and low toxicity and are suitable for oral administration.

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Nurnberg, Germany

Walter Otto Liebenow