University of Washington

Walter Novak

David Baker

Marc J Lajoie

Scott Boyken

Robert A Langan

Alfredo Quijano Rubio

Disclosed are protein switches that can sequester bioactive peptides and/or binding domains, holding them in an inactive ('off') state, until combined with a second designed polypeptide called the key, which induces a conformational change that activates (“on”) the bioactive peptide or binding domain, components of such protein switches, and their use.

De novo design of protein switches

Disclosed are protein switches that can sequester bioactive peptides and/or binding domains, holding them in an inactive ('off') state, until combined with a second designed polypeptide called the key, which induces a conformational change that activates ('on') the bioactive peptide or binding domain, components of such protein switches, and their use.

Growing community of inventors

Seattle, WA, United States of America

Walter Novak