Ucp Gen-pharma Ag

Ciba-geigy Corporation a Corp. of New York

Walter M&auml;rki

Jutta Heim

Hans Rink

Peter Sieber

Bernd Meyhack

Hans Fritz

Werner Rittel

Sefik Alkan

Manfred Liersch

Francois Meyer

Ursula Seem&uuml;ller

A method for the production and secretion of proteins with hirudin activity in an eukaryotic host organism is provided. There are also provided hybrid vectors comprising a DNA sequence encoding a signal peptide upstream of and in reading frame with the structural gene for desulphatohirudin, and eukaryotic host organisms transformed with said hybrid vectors.

Production of thrombin inhibitors

The invention relates to DNA sequences which code an eglin, expression plasmids containing such DNA sequences, hosts transformed with such expression plasmids, novel eglin compounds produced from such transformed hosts, monoclonal antibodies against eglins, hybridoma cells which produce such antibodies, and test kits for immunoassays containing such antibodies, and furthermore the processes for their preparation and a process for the preparation of eglins with the aid of the transformed hosts. The eglins which can be prepared according to the invention have useful pharmacological properties.

Process for preparing recombinant eglin, protease inhibitor

Growing community of inventors

Möhlin, Switzerland

Walter Märki

Growing community of inventors

Möhlin, Switzerland

Walter M&auml;rki

Walter Märki