Synta Pharmaceuticals Corporation

Sirtris Pharmaceuticals, Inc.

R.p.scherer Technologies, Inc.

Walter Lunsmann

Pui Yee Ng

Jean E Bemis

Chi B Vu

Michael R Jirousek

Jeremy S Disch

Ninad Deshpanday

Juha-Matti Savola

Susan Gerrard Banbury

Leon Grother

Päivi Juujärvi

Owen Murray

Paivi Juujarvi

Leon P Grother

Improved formulations containing substituted imidazole derivatives of the general formula 1, formula (I) wherein Y is &#x2014;CH&#x2014; or &#x2014;CO&#x2014;, Ris H, halo or hydroxy, Ris H or halo, and Ris H or lower alkyl (e.g. Cto Calkyl, preferably Cor Calkyl), or a pharmaceutically acceptable salt, such as an acid addition salt, e.g. the hydrochloride, of a compound of the general formula (I), are in solid fast-dispersing dosage form suitable for pre-gastric absorption. 

Formulations containing substituted imidazole derivatives

Disclosed herein are compositions comprising a compound represented by structural formula (I): 2 g of which is reconstitutable in 10 mL of a water in less than 10 minutes, and methods for preparing these compositions. Also disclosed are compositions comprising a compound represented by structural formula (I) and a pharmaceutically acceptable excipient, wherein the molar ratio of said compound to said excipient is from 1:20 to 1:1, and methods for preparing these compositions.

Bis(thio-hydrazide amide) formulation

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

Sirtuin modulating compounds

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

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Harvard, MA, United States of America

Walter Lunsmann