Bayer Aktiengesellschaft

Lanxess Deutschland Gmbh

Walter Lange

Rolf Grosser

Bruno Bomer

Dieter Arlt

Michael Grosse-Bley

Dietmar Bielefeldt

Markus Eckert

Franz-Peter Hoever

Joachim Komoschinski

Uwe Zweering

Bruno B&ouml;mer

Claus Dreisbach

Michael Dockner

Thomas Prinz

Henry Giera

Guido Giffels

Burkhard K&ouml;hler

Joachim Kralik

Inga Ritzkopf

Christian Steffens

Stefan Michel

Birgit Driessen-H&ouml;lscher

Wolfgang Podszun

Burkhard Kohler

Andreas Krebs

Guido Steffan

Ernst Kysela

Hanns-Ingolf Paul

Albert Schnatterer

Karl-Rudolf Gassen

Herbert Diehl

Raul Pires

Adolf Sicheneder

Christoph Schild

Wolfram Sirges

Michaela Meiers

Dietrich Seidel

Torsten Pohl

Bruno Bomer, Deceased

By Guido Bomer

Elvira Krebs, Legal Representative

Tobias Reichelt

The present invention relates to a process for the enantiomeric enrichment of cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane with the aid of continuous countercurrent chromatography, which is also described as SMB chromatography (SMB=simulated moving bed). In a further aspect, the invention relates to a process for the preparation of (1S,6R)-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane using the aforementioned process, which furthermore includes a racemization step.

Process for the enantiomeric enrichment of cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane

Polyhalogenated cinnamic acids and cinnamic acid derivatives are prepared by reacting diazonium salts accessible from polyhalogenated anilines with acrylic acid or acrylic acid derivatives in the presence of a homogeneous, palladium-containing catalyst at about &#x2212;5 to about +100&#xb0; C. Some of the cinnamic acids and cinnamic acid derivatives obtainable in this way are new. Cinnamic acids and cinnamic acid derivatives which can be prepared according to the invention can be used for the preparation of indanones which are precursors for agro- and pharmaceutical chemicals and for substances having liquid-crystalline properties.

Polyhalogen-substituted cinnamic acids and cinnamic acid derivatives and a process for the preparation of polyhalogen-substituted cinnamic acids and cinnamic acid derivatives

The present invention encompasses a process for preparing arylolefins by reacting one or more arylamines with one or more organic nitrites, in the presence of one or more olefins which bear at least one hydrogen atom on the double bond and in the presence of acid and in the presence of palladium or one or more palladium compounds.

Process for the arylation of olefins

The present invention relates to the use of optically active polymers of N-acryloyl-phenylalanine neomenthylamide as such, in crosslinked form and/or in carrier-bonded form as stationary phases for the chromatographic separation of enantiomers of lactones.

Chromatographic separation of enantiomers of lactones

Diphosphines

The invention relates to novel optically active polymerizable dipeptides, to the process for the preparation thereof, to the polymerization thereof and to the use of the polymers as adsorbents for the chromatographic separation of enantiomers.

Polymers chromatographic separation of enantiomers

The invention relates to substituted cinnamic acids and cinnamic acid esters of formula (I), wherein X represents F, Cl or J and R and R are the same or different and represent hydrogen, an optionally substituted C -C -alkyl radical or an optionally substituted benzyl radical. Substituted indanone carboxylic acid esters are produced using said substituted cinnamic acid and cinnamic acid ester in a technically simple and non-dangerous manner as far as safety is concerned.

Substituted cinnamic acids and cinnamic acid esters

The invention relates to a process for the preparation of nitrosobenzenes from aromatic amines by oxidation with hydrogen peroxide in the presence of sodium molybdate dihydrate and an inert organic solvent.

Process for the preparation of nitrosobenzenes

Chromatographic enantiomer separation of lactones

The invention relates to a process for the preparation of nitrodiphenylamines by reaction of nitrohalogenobenzenes with aromatic amines in the presence of a palladium catalyst and a base, the base being ground and/or dried before its use.

Process for the preparation of nitrodiphenylamines

The invention relates to chiral polymers which are bonded to a support and have improved properties, a process for the preparation of these materials and their use as chiral stationary phases in the chromatograhic separation of optical isomers, in particular of racemates into their enantiomers.

Chiral stationary phases for chromatographic separation of optical

The invention relates to new optically active sulphur-containing amino acid derivatives, a process for their preparation, their polymerization to give optically active polymers and the use of these optically active polymers as adsorbents for chromatographic separation of racemates into enantiomers.

Optically active sulphur-containing amino acid derivatives

The invention relates to new optically active amino acid derivatives of the general formula (I) ##STR1## in which n, R, R.sub.1, R.sub.2, R.sub.3, X and A have the meaning given in the description, which amino acid derivatives contain sulphoxide or sulphone groups, to two basic synthetic routes for the preparation from sulphur-containing amino acids, to the polymerization of these monomers and to the use of the polymers as optically active adsorbents for chromatographic resolution of racemates to give the enantiomers.

Optically active amino acid sulphoxide and amino acid sulphone

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Odenthal, Germany

Walter Lange