Teva Pharmaceuticals International Gmbh

Teikoku Pharma USA, Inc.

Birch Point Medical, Inc.

Travanti Pharma Inc.

Walter L Sembrowich

Carter R Anderson

Russell L Morris

Robert Cohen

Clayton Anderson

A disposable skin-worn device for the transdermal delivery at least one dose of charged therapeutic substances, including granisetron, by iontophoresis, the device comprising a donor reservoir containing an amount of a therapeutic substance to be delivered transdermally by iontophoresis, a counter reservoir, a source of electric power connected in a circuit between the donor reservoir and the counter reservoir and a control system for controlling current flow in the circuit to enable at least one dose of the therapeutic substance to be delivered transdermally by iontophoresis and wherein the control system includes a control element selected from the group consisting of a sensor activated by an external signal and a switch.

Transdermal systems for the delivery of therapeutic agents including granisetron using iontophoresis

A planar disposable transdermal iontophoretic delivery system is disclosed which includes amounts of an oxidizable species and a reducible species connected by a common conductor forming a galvanic battery for serving as the sole source of power and control for the system, an amount of a therapeutic agent is provided to be driven through the skin of a patient solely through the use of the galvanic battery. The galvanic battery is provided with a lot-tested coulombic capacity rating to predict dosage.

Controlled dosage drug delivery

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North Oaks, MN, United States of America

Walter L Sembrowich