Takeda Pharmaceutical Company Limited

Senomyx, Inc.

Other

Walter Keung

Jon Elliot Adler

Shawn O'Connell

Guy Servant

Alexey Pronin

Huixian Tang

Paul Brust

Judy Connor

Zhe Li

Anthony R Gangloff

Steven John Woodhead

Jeffrey Alan Stafford

Stephen W Kaldor

Benjamin Jones

Nicholas Scorah

Andre A Kiryanov

John S Tyhonas

Phong H Vu

Mark Sabat

Haixia Wang

Lily Kwok

Craig A Behnke

Steve Swann

Simone Bigi

Disclosed are compounds of formula 1: which are useful as inhibitors of TBK1. Also disclosed are pharmaceutical compositions which contain the compounds, methods for treatment of conditions associated with TBK1, and processes for making the compounds and intermediates thereof.

Heteroarylamide inhibitors of TBK1

The present invention provides compounds of formula 1: which are useful as inhibitors of TBK-1, pharmaceutical compositionst thereof, methods for treatment of conditions associated with TBK1, processes for making the compounds and intermediates thereof.

The invention relates to compounds having the formulae: wherein the variables are as defined herein. The invention further relates to methods of making and using these compounds, and pharmaceutical compositions, kits and articles of manufacture comprise the compounds.

Renin inhibitors

The invention relates to compounds having the formula: wherein the variables are as defined herein. The invention further relates to methods of making and using these compounds, and pharmaceutical compositions, kits and articles of manufacture comprise the compounds.

Assays for identifying compounds that modulate, preferably inhibit bitter taste associated with the activation of hT2R4, hT2R44 and/or hT2R61 are provided. The compounds identified according to these assays should modulate, e.g., inhibit bitter taste associated with bitter tasting compounds including quinine, 6-nitrosaccharin, saccharin and/or denatonium. These compounds are useful additives for foods, beverages or medicinal preparations having a bitter taste.

Use of specific T2R taste receptors to identify compounds that block bitter taste

Assays for identifying compounds that modulate, preferably inhibit bitter taste associated with the activation of hT2R4, hT2R44 and/or hT2R61 are provided. The compounds identified according to these assays should modulate, e.g., inhibit bitter taste associated with bitter tasting compounds including quinine, 6-nitrosaccharin, saccharin and/or denatonium. These compounds are useful additives for foods, beverages or medicinal preparationshaving a bitter taste.

Use of specific T2R receptors to identify compounds that block bitter taste

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San Diego, CA, United States of America

Walter Keung