Monsanto Technology LLC

Walter K Gavlick

David R Eaton

Eric A Haupfear

James P Coleman

David Z Becher

Arnold Hershman

Denis Forster

Eduardo Aurelio Casanova

Peter E Rogers

Lowell R Smith

Stephen D Prosch

Donald D Soleta

Mark D Scaia

Robert E Byrd

John Wagenknecht

Gary Klopf

Leonard Aynardi

Oliver Lerch

Carl Mumford

Alfredo Oba

Bart Roose

This invention relates to the preparation of N-(phosphonomethyl)glycine ('glyphosate') from N-(phosphonomethyl)iminodiacetic acid ('PMIDA'), and more particularly to methods for control of the conversion of PMIDA, for the identification of reaction end points relating to PMIDA conversion and the preparation of glyphosate products having controlled PMIDA content. One such method involves obtaining a series of Fourier transform infrared (&#x201c;FTIR&#x201d;) analyses of the PMIDA content of the aqueous reaction medium or a sample thereof during the course of the reaction. From a plurality of FTIR analyses, a projection is made of the batch reaction time or continuous oxidation residence time within the oxidation reaction zone at which a target conversion or end point may be anticipated to be attained or is attained.

Control of n-(phosphonomethyl)iminodiacetic acid conversion in manufacture of glyphosate

This invention relates to the preparation of N-(phosphonomethyl)glycine ('glyphosate') from N-(phosphonomethyl)iminodiacetic acid ('PMIDA'), and more particularly to methods for control of the conversion of PMIDA, for the identification of reaction end points relating to PMIDA conversion and the preparation of glyphosate products having controlled PMIDA content.

Control of N-(phosphonomethyl)iminodiacetic acid conversion in manufacture of glyphosate

The present invention is directed to an analytical method for measuring the concentration of an N-(phosphonomethyl)iminodiacetic acid (&ldquo;NPMIDA&rdquo;) substrate, an N-(phosphonomethyl)glycine product, formaldehyde, formic acid, N-methyl-N-(phosphonomethyl)glycine (&ldquo;NMG&rdquo;), N-methyl-aminomethylphosphonic acid (MAMPA) or aminomethylphosphonic acid (&ldquo;AMPA&rdquo;)) in an aqueous mixture thereof, using infrared spectroscopy. The present invention is also directed to a process for oxidizing an N-(phosphonomethyl)iminodiacetic acid substrate to form a N-(phosphonomethyl)glycine product, and as part of the process, measuring the concentration of at least one reactant, product or byproduct of the oxidation reaction using the analytical method of the present invention and controlling the oxidation process in response to the measurement taken.

Use of infrared spectroscopy for on-line process control and endpoint detection

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Chesterfield, MO, United States of America

Walter K Gavlick