Johns Hopkins University

Iatrotech, Inc.

Walter J Stark

Justin Scot Hanes

Jin Yang

Jeffrey L Cleland

Ming Yang

Jie Fu

Deborah K Hall

Qingguo Xu

Joshua Kays

Erik Rencs

Lixia Luo

Bing Wang

Nicholas J Boylan

Qing Pan

Yun Yu

Particles encapsulating a glucocorticoid such as dexamethasone sodium phosphate (DSP) into a matrix such as biodegradable poly(lactic-coglycolic acid) (PLGA) which is densely coated with hydrophilic polymer such as PEG or PLURONIC&#xae; F127, exhibit sustained release of DSP for up to 7 days in vitro. These nanoparticles can be used to prevent corneal graft rejection or corneal neovascularization.

Glucocorticoid-loaded nanoparticles for prevention of corneal allograft rejection and neovascularization

A phantom cornea for calibrating surgical lasers is formed by superimposition of thin-films of alternating colors. After ablation by a laser beam, the resulting spherical cavity appears as a pattern of nested circles whose concentricity and spacing reflect the alignment and intensity of the laser beam. These patterns can be visually or instrumentally analyzed to determine the proper setting of the laser. The calibration cornea can be planar, or arcuate to mimic the natural cornea. The calibration cornea may be mounted in a phantom eyeball including a removable iris of small diameter which constitutes a convenient target for the alignment of the laser beam.

Surgical refractive laser calibration device

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Baltimore, MD, United States of America

Walter J Stark