Janssen Pharmaceutica Nv

Walter Herman Maria Louis Luyten

Marianne Denise De Backer

Bart Jozef Maria Nelissen

Roland Henri Contreras

Jorge Eduardo Vialard

Eckhard Bender

Mirek Jurzak

Russell Tony Masell Poulter

Armelle Nathalie Françoise Pindon

Irma Petronella Van Oers

Jasmine Elza Viaene

Marc George Logghe

The present invention is concerned with the identification of genes or functional fragments thereof fromwhich are critical for growth and cell division and which genes may be used as selective drug targets to treatassociated infections. Novel nucleic acid sequences fromare also provided and which encode the polypeptides which are critical for growth of. Methods for the identification of anti-fungal compounds which inhibit fungal or yeast growth are also contemplated.

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TCa2 is a Tyl/copia retrotransposon from the pathogenic yeast. In contrast to other retrotransposons it can appear as an abundant, extrachromosomal double-stranded DNA molecule, called pCal. The invention relates to the isolation and characterisation of TCa2 and pCal together with its uses for inducing random mutagenesis in a genome, as a component of a transposable element and of an expression vector.

There is disclosed an isolated or substantially pure form of a nucleic acid molecule encoding a human 5-HTreceptor, which 5-HTreceptor preferably comprises the sequence illustrated in FIG.B. Also provided by the invention are expression vectors incorporating said nucleic acid molecule in addition to transgenic cells, tissues or organisms transfected with the nucleic acid molecule.

Cloning and expression of a novel 5-HT4 receptor

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Beerse, Belgium

Walter Herman Maria Louis Luyten