Boehringer Ingelheim Gmbh

Dr. Karl Thomae Gesellschaft MIT Beschrankter Haftung

Dr. Karl Thomae Gmbh

Karl Thomae Gmbh

Walter Haarmann

Erich Muller

Josef Nickl

Berthold Narr

Josef Roch

Johannes M Weisenberger

Herbert Koppe

Wolfhard Engel

Werner Kummer

Helmut Stahle

Gunter Trummlitz

Ernst Seeger

Gunther Engelhardt

Wolfgang Schroter

Wolfgang Eberlein

Volkhard Austel

Joachim Heider

Richard Reichl

Willi Diederen

Rainer Zimmermann

Rudolf Kadatz

Rudolf Hurnaus

Walter Kobinger

Wolfgang Grell

Christian Lillie

Robert Sauter

Eckhard Rupprecht

Gerhart Griss

Eberhard Kutter

Bernhard Eisele

Helmut Teufel

Jurgen Krause

Helmut Ballhause

Hans W Schroter

Johannes-Maximilian Weisenberger

Benthold Narr

Laurence A Harker

A method of determining the total fibrinolytic activity in plasma, is characterized in that

Method of determining the total fibrinolytic activity in the plasma

Compounds of the formula ##STR1## wherein R.sub.1 is a substituted alkoxy group, or an optionally substituted mercapto or amino group,

2-(perhydro-1,4-diazino)-pyrimido[5,4-d]-pyrimidines and salts thereof

2-(Perhydro-1,4-diazino)-pyrimido(5,4-D)-pyrimidines, pharmaceutical

This invention relates to a compound of formula (I) ##STR1## wherein R.sub.1 and R.sub.2 are each independently hydrogen, C.sub.1 -C.sub.3 alkyl or C.sub.1 -C.sub.3 alkoxy; and R.sub.3 is a C.sub.7 -C.sub.9 aralkyl, the phenyl nucleus of which can be mono-, di-, or trisubstituted by halogen, C.sub.1 -C.sub.3 alkyl or C.sub.1 -C.sub.3 alkoxy, and nontoxic, pharmaceutically acceptable salts thereof. The compounds have useful antithrombic properties.

Quaternary 3,4-dihydro-isoquinolinium salts

Compounds of the formula ##STR1## wherein R.sub.1 is phenylalkylamino, alkylamino, dialkylamino, piperidino, morpholino, thiomorpholino or 1-oxido-thiomorpholino;

2-Piperazino-pteridines useful as antithrombotics and antimetastatics

Compounds of the formula ##STR1## wherein n is 0 or 1;

Antithrombotic sulfoximino carbostyrils

Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, methyl, methoxy, fluorine or chlorine; and

Antithrombotic

Antithrombotic use of 2-(perhydro-1,4-diazino)-pyrimido

This invention is directed to novel benzoxazin-2-ones of the formula ##STR1## wherein A is a sulfur atom or an SO, SO.sub.2, R--N.dbd.S, or R--N.dbd.SO.sub.2 group where R is a hydrogen atom or an acyl group;

Substituted benzoxazin-2-ones and pharmaceutical compositions containing

Compounds of the formula ##STR1## wherein R.sub.1 is optionally substituted alkyl;

Trisubstituted pyrimido[5,4-d]pyrimidines and salts thereof

Antithrombotic sulfimino and sulfoximino indolinones-2

Compounds of the formula ##STR1## wherein n and m are each 1, 2 or 3, and the sum of n+m is 4;

Azepine derivatives and their anti-thrombotic compositions and methods

Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen; trifluoromethyl; alkyl of 1 to 11 carbon atoms; cycloalkyl of 3 to 7 carbon atoms; hydroxyl; alkoxy of 1 to 6 carbon atoms; mercapto; (alkyl of 1 to 6 carbon atoms)-mercapto; phenyl-(alkyl of 1 to 3 carbon atoms); phenyl; or mono-, di- or tri-substituted phenyl, where the substituents, which may be identical to or different from each other, are each halogen, alkyl of 1 to 4 carbon atoms, (alkyl of 1 to 6 carbon atoms)-sulfinyl, hydroxyl, alkoxy of 1 to 6 carbon atoms, mercapto or (alkyl of 1 to 6 carbon atoms)-mercapto;

Pyridazinone-substituted benzimidazoles and salts

Compounds of the formula ##STR1## wherein W is vinylene, methyl-vinylene, methylene or ethylene;

Cardiotonic and antithrombotic sulfur-containing derivatives of

Compounds of the formula ##STR1## wherein R.sub.1 is unsubstituted, mono-substituted or di-substituted piperidino, where the substituents are selected from the group consisting of methyl, hydroxymethyl, hydroxyl, phenyl and benzyl;

3-Amino-4-phenyl-6-piperidino-1H-pyrazolo[3,4-b]-pyridines and salts

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Biberach, Germany

Walter Haarmann