Harvard College

Biogen, Incorporated

Walter Gilbert

Argiris A Efstratiadis

Richard A Fisher

Vicki L Sato

Lydia J Villa-Komaroff

Stephanie A Broome

Kuzhalmannam L Ramachandran

Karen Talmadge

Johann J Leban

This invention relates to peptides involved in the pathogenesis of human immunodeficiency virus ('HIV'). More particularly, this invention relates to peptides from the env region of the HIV genome and the use of such peptides in methods and compositions for preventing, treating, or detecting acquired immune deficiency syndrome ('AIDS') infection.

Peptides involved in the pathogenesis of HIV infection

A plasmid or phage gene for a periplasmic or extracellular bacterial protein is cleaved, a double-stranded DNA sequence coding for a selected protein or portion thereof from a eukaryotic cell such as insulin is inserted in that cleaved gene by recombinant DNA techniques and used to transform a bacterium, and the excreted selected protein is collected.

Recombinant DNA molecule

Protein synthesis

A method is provided for synthesizing within a bacterial host, and secreting through the membrane of the host, a selected mature protein or polypeptide. The method involves:

Mature protein synthesis

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Cambridge, MA, United States of America

Walter Gilbert