Carl-zeiss-stiftung

Walter Geis

Manfred Meyer

Hans Brinkmann

Wilhelm Ansorge

Hans Gausmann

Albrecht Kettler

Volker Wilke

Hubert Nasse

A linear guide includes rolling bodies that are inserted into mutually corresponding grooves of mutually guided parts. The guide surfaces for the rolling bodies are partially formed by plane surfaces of rotatable beveled round rods that are positioned in the grooves. The linear guide is constructed as a double guide on both sides with respectively two spaced-apart guide grooves on mutually opposed sides of the mutually guided parts. Because the guide surfaces are partially formed by the plane surfaces of the rotatable beveled round rods, wedge angles between the mutually guided parts are compensated. Manufacturing technical requirements regarding the matching of the distances of the guide grooves to each other are thereby greatly reduced.

Linear guide with rolling bodies

A drive system for the conversion of a rotary motion into a linear motion contains a belt drive similar to a block and pulley system, and a system of a rack and pinion that is driven synchronously with the belt drive. The pinion and the rack are adjusted with respect to each other such that the teeth of the pinion engage with relatively large play in the rack. When driving under normal load, the drive takes place without loading of the rack and pinion system by the belt drive, so that the reversal backlash and the play of the rack and pinion system remain without effect on the displacement motion. When an overloading of the moving part and a corresponding stretching of the drive belt occur, the tooth flanks of the pinion and of the rack are supported against each other and in this manner prevent tearing or overloading of the drive belt. The drive system has a high reproducibility and a small reversal back-lash, and is particularly applicable for the drive of the focusing motion in microscopes with automatic repositioning by means of a drive motor.

Drive system for the motion of a moving equipment part

The invention is an inverted microscope with a housing having multiple integrated ray paths leading from the specimen being examined to (a) the viewer/operator and (b) one or more auxiliary ports used for image recording and/or measurement by accessories such as cameras and video recorders. The microscope lens is positioned below the specimen stage; and, positioned below the lens, is a simple reflector which deflects the combined rays from the lens diagonally upward toward the viewer at exactly the same angle at which the viewer looks into the microscope's binocular eyepieces. The position of this simple reflector is the lowest point in the unit's paths of rays, thereby significantly lowering the lens turret and, therefore, the specimen stage to a relatively low, ergonomically-appropriate position. The optical arrangement is simple and compact, minimizing the number of deflections in the path of the viewing rays. Further, light from the microscope lens is deflected along the second path to the auxiliary port and the recording camera by an optical element which is positioned above the reflector in the diagonally-upward path of rays, thereby providing ample room at the auxiliary port to permit use of a recording camera having an automatic-rewind housing. The invention also includes removable and interchangeable tubes which include viewing binoculars and/or an additional auxiliary image port positioned along a vertical path of rays and/or a further additional auxiliary image port positioned along a horizontal path of rays.

Inverted microscope with integrated ray paths

The invention is an inverted microscope with a housing having multiple integrated ray paths leading from the specimen being examined to (a) the viewer/operator and (b) one or more auxiliary ports used for image recording and/or measurement by accessories such as cameras and video recorders. The microscope lens is positioned below the specimen stage; and, positioned below the lens is a simple reflector which deflects the combined rays from the lens diagonally upward toward the viewer at exactly the same angle at which the viewer looks into the microscope's binocular eyepieces. The position of this simple reflector is the lowest point in the unit's paths of rays, thereby significantly lowering the lens turret and, therefore, the specimen stage to a relatively low, ergonomically-appropriate position. The optical arrangement is simple and compact, minimizing the number of deflections in the path of the viewing rays. Further, light from the microscope lens is deflected along the second path to the auxiliary port and the recording camera by an optical element which is positioned above the reflector in the diagonally-upward path of rays, thereby providing ample room at the auxiliary port to permit use of a recording camera having an automatic-rewind housing. The invention also includes removable and interchangeable tubes which include viewing binoculars and/or an additional auxiliary image port positioned along a vertical path of rays and/or a further additional auxiliary image port positioned along a horizontal path of rays.

The invention is directed to a method for performing work on cells of a cell culture which includes microinjecting cells in the cell culture or drawing liquid from an individual cell or withdrawing whole cells with the aid of suction from the cell culture. The system is computer-supported and a marker movable in the image on a monitor is superposed on a television image of the cell culture. The marker is positioned in the television image on the cell to be injected by the operator by means of a relative movement of the marker with respect to the image. The coordinates of the cells marked in this way are stored by the computer which thereafter advances the capillary point automatically to the selected cells and penetrates the latter. Pursuant to a feature of an advantageous embodiment of the invention, the computer guides the penetration movement parallel to the longitudinal axis of the capillary by means of a superposed movement (k) of the object stage and through a superposed movement of the drive for the elevation displacement (z) of the capillary on the micromanipulator.

Method for performing work on cells of a cell culture and apparatus

The invention contemplates a cuvette or cell construction which is especially adapted to enable photometer or the like measurement of sample fluid admitted to the measurement chamber of the cell. The construction is applicable to fluid analysis under either the condition of a continuous-flow of specimen fluid, or under the condition that a single small sample has been vacuum-induced into the measurement chamber. The construction is inherently simple, is inherently self-clearing of air or gas bubbles in liquid samples, and provides inherently efficient cleansing of the measurement chamber when examined sample is withdrawn.

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Aalen, Germany

Walter Geis