Other

Walter G M Schmidt

David T Curiel

Matthew Cotten

Ernst Wagner

Max L Birnstiel

Kurt Zatloukal

Berndt Oberhauser

Christian Plank

A composition for the transfection of higher eucaryotic cells, comprising complexes of nucleic acid, a substance having an affinity for nucleic acid and optionally an internalizing factor, contains an endosomolytic agent, e.g. a virus or virus component, which may be conjugated. The endosomolytic agent, which is optionally part of the nucleic acid complex, is internalized into the cells together with the complex and releases the contents of the endosomes into the cytoplasm, thereby increasing the gene transfer capacity. Pharmaceutical preparations, transfection kits and methods for introducing nucleic acid into higher eucaryotic cells by treating the cells with the composition are also disclosed.

Composition for introducing nucleic acid complexes into higher eucaryotic cells

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Vienna, Austria

Walter G M Schmidt