Board of Trustees of the University of Arkansas

The Texas A&m University System

University of Guelph

Walter G Bottje

Billy M Hargis

Luc Berghman

Sherryll Layton

Young Min Kwon

Kimberly Cole

Mandy Cox

John R Barta

Guillermo Tellez

Robert Frederick Wideman, Jr

Saeed El-Ashram

Said El-Ashram

Michael T Kidd

Vaccines comprising TRAP polypeptides andvectors comprising TRAP polypeptides are provided. The vaccines may also include a CD154 polypeptide capable of binding to CD40. Also provided are methods of enhancing an immune response against Apicomplexan parasites and methods of reducing morbidity associated with infection with Apicomplexan parasites.

Compositions and methods of enhancing immune responses to

Compositions and methods of enhancing immune responses to Eimeria

Provided herein are13A strains and compositions comprising these strains. Also provided are methods of enhancing an immune response against Influenza A and methods of reducing morbidity associated with an Influenza A infection. Methods of enhancing an immune response to a vaccine vector by expressing a polypeptide of CD154 capable of binding CD40 are also disclosed. Methods of developing a bacterial vaccine vector are disclosed. Methods of generating scarless site-specific mutations in a bacterium are also disclosed.

Compositions and methods of enhancing immune responses

Provided herein are vaccine vectors including an antigenic polypeptide and an HMGB1 polypeptide present on the surface of the vaccine vector. Compositions comprising the vaccine vectors are also provided and include a pharmaceutically acceptable carrier, suitably a carrier for oral or nasal administration. Also provided are methods of enhancing immune responses, in particular antibody immune response and suitably an IgA response, by administering the vaccine vectors or compositions disclosed herein to a subject.

Vaccine vectors and methods of enhancing immune responses

Vaccines comprising fliC and CD 154 polypeptides andvaccine vectors comprising fliC polypeptides are provided. Also provided arc methods of enhancing an immune response against flagellated bacteria and methods of reducing morbidity associated with infection with flagellated bacteria.

Compositions and methods of enhancing immune responses to flagellated bacterium

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Provided herein are13A strains and compositions comprising these strains. Also provided are methods of enhancing an immune response against Influenza A and methods of reducing morbidity associated with an Influenza A infection. Methods of enhancing an immune response to a vaccine vector by expressing a polypeptide of CD 154 capable of binding CD40 are also disclosed. Methods of developing a bacterial vaccine vector are disclosed. Methods of generating scarless site-specific mutations in a bacterium are also disclosed.

A method of treating an avian egg, including the step of administering to an avian egg a sufficient amount of an L-arginine compound to prevent pulmonary hypertension syndrome in an avian to be hatched from the egg.

In ovo use of L-arginine and salts thereof in the prevention and/or

A method of treating or preventing pulmonary hypertension syndrome in avians, generally including administering a drinking water containing L-arginine compound to the avian.

Growing community of inventors

Fayetteville, AR, United States of America

Walter G Bottje