Statens Serum Institut

Walter Florio

Peter Andersen

Peter Birk Rasmussen

Karin Weldingh

Rikke Louise Vinther Skjot

Christina Veggerby Hansen

Li Mei Meng Okkels

Ida Rosenkrands

Thomas Oettinger

Rikke Nielsen

The present invention is based on the identification and characterization of a number of novelderived proteins and protein fragments. The invention is directed to the polypeptides and immunologically active fragments thereof, the genes encoding them, immunological compositions such as diagnostic reagents containing the polypeptides.

[object Object]

TB diagnostic based on antigens from M. tuberculosis

The present invention is based on the identification and characterization of a number of derived novel proteins and protein fragments (SEQ ID NOs: 2, 4, 6, 8, 10, 12, 14, 16, 17-23, 42, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68, 70, 72-86, 88, 90, 92, 94, 141, 143, 145, 147, 149, 151, 153, and 168-171). The invention is directed to the polypeptides and immunologically active fragments thereof, the genes encoding them, immunological compositions such as vaccines and skin test reagents containing the polypeptides. Another part of the invention is based on the surprising discovery that fusions between ESAT-6 and MPT59 are superior immunogens compared to each of the unfused proteins, respectively.

Nucleic acids fragments and polypeptide fragments derived from M. tuberculosis

Growing community of inventors

Carrara, Italy

Walter Florio