Assoicated Universties, Inc.

Harvard College

The Broad Institute, Inc.

Rijksuniversiteit Groningen

Walter F Mangel

Carl W Anderson

Paul Blainey

Xiaoliang Sunney Xie

Andreas Herrmann

Vito Graziano

William J McGrath

Antonius Martinus Van Oijen

The present invention relates to compositions which may comprise a molecular sled linked to cargo and uses thereof. In particular, the present invention relates to a non-naturally occurring or engineered composition which may comprise a molecular sled, linkers and a molecular cargo connected to the sled via the linkers. Methods involving the use of molecular sleds and their cargoes and pharmaceutical compositions, methods for treating cancer, a degenerative disease, a genetic disease or an infectious disease as well as diagnostic methods are also contemplated by the present invention.

Molecular sleds and uses thereof

This application describes methods and expression constructs for producing activatable recombinant adenovirus proteinases. Purified activatable recombinant adenovirus proteinases and methods of purification are described. Activated adenovirus proteinases and methods for obtaining activated adenovirus proteinases are further included. Isolated peptide cofactors of adenovirus proteinase activity, methods of purifying and identifying said peptide cofactors are also described. Antibodies immunoreactive with adenovirus proteinases, immunospecific antibodies, and methods for preparing them are also described. Other related methods and materials are also described.

Activated recombinant adenovirus proteinases

Co-factor activated recombinant adenovirus proteinases

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Shoreham, NY, United States of America

Walter F Mangel