Ciba Corning Diagnostics Corp.

Corning Incorporated

Corning Glass Works

Chiron Corporation

Walter F Love

Rudolf E Slovacek

Thomas A Cook

Richard L Schulkind

Irene M Walczak

George Edward Berkey

Roger J Araujo

Donald B Keck

Yanming Liu

Daiping Ma

The present invention provides an optical fiber, comprising a core having an alpha parameter in the range of approximately 2 to approximately 8, a maximum index percent difference between the core and a cladding in the range of approximately 0.3% to approximately 0.5% and a core diameter in the range of approximately 6.0 to approximately 16.0 &mgr;m and a cladding. The optical fiber has a bandwidth of at least approximately 0.6 GHz.km at 850 nm, and is configured for multimode operation at a wavelength less than 1300 nm and single mode operation at a wavelength of at least approximately 1300 nm. The fiber also has significantly reduced intermodal noise. The present invention also includes a method of designing such a fiber, a fiber optic system provided such a fiber and a method of operating a fiber optic system with such a fiber.

Broadband access optimized fiber and method of making

An evanescent wave system and method including an optical sensor for use in assaying a reference material and at least one molecular species or analyte in a test medium or test sample for diagnostic and other applicable purposes. The sensor includes a waveguide for propagating a radiation input along its length. The radiation input causes evanescent electromagnetic waves that are capable of stimulating output emissions that are indicative of a reference material and of one or more molecular species or analytes. By comparing the emission(s) indicative of the reference material to the emission indicative of the presence of the molecular species or analyte, the presence and concentration of the molecule in the sample can be determined. The reference material provides for normalization and/or calibration of the system.

Multiple output referencing system for evanescent wave sensor

An evanescent wave sensor and method for use in analyzing one or more media, the sensor including a waveguide having first and second wave propagating surfaces. The waveguide propagates an input signal along the waveguide between the first and second surfaces. The first surface receives a first radiation signal which indicates the presence of a first analyte, and the second surface receives a second radiation signal representing one or both of a second analyte and a reference. The first and second surfaces can both be contacted with a single medium, or with two separate media, and one or more output signals can be detected.

Multiple surface evanescent wave sensor with a reference

A method of dealkalizing a glass body that contains at least one alkali metal ion as either an impurity or an intentionally added constituent. The method involves intimately contacting the glass body with a hydrogen-ion-producing anode and an oxide receptor for the alkali metal ion as a cathode and exposing the glass body and electrode assembly to hydrogen while the assembly is at an elevated temperature.

Method of dealkalizing glass

An evanescent wave sensor for use in analyzing a medium, the sensor including a shell having a radiation port at a first end and a base at a second end. The base has a dimension greater than that of the radiation port, and inner and outer wall surfaces of the shell extend between the radiation port and the base. The shell is formed of a material having an index of refraction greater than that of the medium. An apparatus and method for analyzing the medium using the sensor may include a receptacle which defines a chamber about a portion of the shell for contacting the medium to the shell for analysis, optical elements for guiding radiation from a radiation source to the radiation port, and optical elements for guiding fluorescent radiation from the shell to a detector of fluorescent radiation.

Evanescent wave sensor shell and apparatus

The present invention relates to novel dielectric waveguide (i.e., fiber optic) sensors for use in spectrophotometric assays of analytes in fluids. More particularly, the use of these sensors in immunoassays is disclosed.

Dielectric waveguide sensors and their use in immunoassays

The present invention relates to a novel evanescent wave sensor which can have a high numerical aperture and is capable of being used in various forms of optically-based assays. Unlike previous fiber optical devices, the present sensors do not use any cladding at the contact points.

Evanescent wave sensors

An optical waveguide mode scrambler including a length of high-alpha optical waveguide optically coupled to a length of low-alpha optical waveguide which provides efficient spatial and angular mixing of light propagating therethrough is described.

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Horseheads, NY, United States of America

Walter F Love