Warner-lambert Company

Walter E Behnke

Theodore H Haskell

Ronald E Seamans

William R Marsh

Phosphate salts of the substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acid are produced by treating a suitably substituted octahydro-1H-indole with phosphoric acid. The phosphate salts of the compounds and pharmaceutical compositions thereof are useful as antihypertensive agents.

Phosphate salts of

Process for the production of an ester product, 9-(.beta.-D-arabinofuranosyl)adenine, 5'-phosphate, in which the mixture resulting from reaction of 9-(.beta.-D-arabinofuranosyl)adenine with phosphorylating agent in trialkyl phosphate solvent is subjected to aqueous hydrolysis, the pH of the hydrolysis mixture is adjusted upward sufficiently to cause separation into aqueous and non-aqueous liquid phases, the trialkyl phosphate solvent is removed, and the product is precipitated from the residual aqueous mixture and isolated.

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St. Clair Shores, MI, United States of America

Walter E Behnke