Hoechst Aktiengesellschaft

Walter Durckheimer

Elmar Schrinner

Rudolf Lattrell

Jurgen Blumbach

Eberhard Ehlers

Gerhard Seibert

Dieter Bormann

Wolfgang Raether

Rene Heymes

Dieter Isert

Reiner Kirrstetter

Friedhelm Adam

Burkhard Mencke

Wilfried Schwab

Karl Seeger

Karl-Heinz Scheunemann

Gerhard Dickneite

Gerd Fischer

Michael Limbert

Hans-Ulrich Schorlemmer

Hubert Georg Seliger

Hans Seidenath

Hans-Harald Sedlacek

Hermann J Gerhards

Ulrich Stache

Jurgen K Sandow

Hans G Alpermann

Walter Petri

Gunter Ditzinger

Wolfgang Martin

Manfred Wieduwilt

Norbert Klesel

Herbert Hartung

Erhardt Winklemann

Burghard Mencke

Klaus Fleischmann

Hans-Peter Merkle

Peter Schmid

Novel crystalline cephem acid addition salts and processes for their preparation

Crystalline cepham acid addition salts and processes for their

Cephem derivatives of the general formula ##STR1## in which the R.sub.2 O group is in the syn-position, a process for their manufacture and pharmaceutical formulations which are active against bacterial infections and contain these compounds.

Cephem derivatives and processes for their manufacture

Cyclopeptides and their use as absorption promoters when applied to the mucosa The invention relates to a compound of the formula I ##STR1## or a physiologically tolerated salt thereof, in which X is a basic L- or D-amino acid,

Cyclopeptides and their use as absorption promoters when applied to the

Crystalline cephem acid addition salts of the general formula II ##STR1## pharmaceutical preparations effective against bacterial infections which contain such cephem derivatives, processes for the preparation of the cephem derivatives and the pharmaceutical preparations, and the use of the cephem derivatives for combating bacterial infections.

Crystalline cephem acid addition salts and process for their preparation

The disclosed invention includes corticoid-17-alkylcarbonates substituted in the 17-position, a process for their preparation and pharmaceuticals containing them. These corticoid-17-alkylcarbonates have the following formula I ##STR1## where A is CHOH in any desired steric arrangement, C.dbd.O or CH.sub.2 ; Y is H, F, or Cl; Z is H, F or CH.sub.3 ; R(1) is O-acyl, carbonylalkyl, alkylsulfonate or arylsulfonate;

Corticoid-17-alkyl-carbonates substituted in the 17-position, process

Cephalosporin derivatives of the general formula ##STR1## pharmaceutical preparations which are active against bacterial infections and contain such cephem derivatives, processes for the preparation of the cephem derivatives and the pharmaceutical preparations and the use of the cephem derivatives for combating bacterial infections.

Cephalosporin derivatives

Cephemcarboxylic acid esters of the general formula ##STR1## pharmaceutical preparations which are active against bacterial infections, which contain such cephem derivatives, a process for the preparation of the cephem derivatives and the pharmaceutical preparations, and also the use of the cephem derivatives for combating bacterial infections.

Cephalosporin derivatives of the general formula ##STR1## pharmaceutical preparations active against bacterial infections which contain such cephalosporin derivatives, processes for the preparation of the cephalosporin derivatives, use of the cephalosporin derivatives for the preparation of a pharmaceutical for combating bacterial infections, and starting products for the preparation of cephalosporin derivatives.

Cephem derivatives

What are disclosed are anti-bacterially active cephalosporin compounds of the formula ##STR1## pharmaceutical preparations containing such compounds, methods of making the compounds, methods for combatting bacterial infections therewith, and intermediates for such compounds.

Penem derivatives of the formula ##STR1## having R.sup.1 equal to 3-oxocyclobutyl and R.sup.2 equal to H or an ester-forming group, pharmaceutical preparations active against bacterial infections and which contain penem derivatives of this type, processes for the preparation of the penem derivatives and the pharmaceutical preparations, and use of the penem derivatives for the control of bacterial infections are described.

Penem derivatives

Crystallized cephem-acid addition salts of the general formula ##STR1## pharmaceutical preparations which contain such cephem derivatives and are active against bacterial infections, a process for the preparation of the cephem derivatives and the pharmaceutical preparations, and the use of the cephem derivatives for combating bacterial infections.

Crystallized cephem-acid addition salts, and a process for the

Heterocyclic sulfides of the general formula heterocycle-S-R, a process for their preparation and, in particular, their use for immunostimulation, immunorestoration and cytostatic treatment, and pharmaceutical agents, which contain a sulfide of this type, for these indications.

1,3-thiazoles and their use as immunomodulators

The use of cephem compounds of the general formula I ##STR1## to increase the immunological responsiveness of mammals and formulations which contain an effective content of cephem compounds of the general formula I.

Growing community of inventors

Hattersheim am Main, Germany

Walter Durckheimer