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Walter Dobler

Joachim Paust

Hansgeorg Ernst

Christian Miller

Gerd Kaibel

Alois Kindler

Udo Rheude

Klaus Breuer

Thomas Dirnsteiner

Wolfgang Siegel

Wolfgang Krause

Werner Aquila

Friedhelm Balkenhohl

Karl Kolter

Manfred Stroezel

Daniel Wagner

Michael John

Carsten Oost

Marcus Sigl

Heinz Etzrodt

Michael Hullmann

Kathrin Meyer-Boehm

Peter Eckes

Achim Pommer

Nicolaus Bahr

Wolf Pelletier

Peter Schording

Jochem Henkelmann

Rainer Becker

Bernhard Rieger

Achim Stammer

Hartwig Voss

Dieter Littmann

Andreas Ansmann

Dieter Hermeling

Hagen Jaedicke

Christof Wilhelm Wigbers

Andreas Keller

Roland Hingmann

Hans-Georg Goebbel

Helmut Jansen

Manfred Eggersdorfer

Stefan Bruhns

Heike Gregorius

Eckhard Ströfer

Mathias Haake

Bernhard Schulz

Bernhard Bockstiegel

Martin Sohn

Wolfram Burst

Klaus Fischer

Susanne Stutz

Klaus Henrich

Arnulf Lauterbach

Björn Kaibel

Christian Tragut

Roland Betz

Wolfgang Huemmer

Hans-Joachim M&uuml;ller

Peter Munster

Carsten S&uuml;ling

Ulf Dietrich

Klaus Reimer

Axel Salden

Thilo Hahn

Thrandur Helgason

Benjamin Nehls

Andreas Habich

Katrin Klass

Otto Worz

Arno Kochner

J&uuml;rgen Matth&auml;us Wagner

Katrin Klaβ

Sabine Schlautmann

Jürgen Deschler

Raajvinder Singh

Armin Bertram

Gunter Dauwel

Juergen Deschler

The present invention relates to dust-free preparations dispersible in cold water. These preparations consist of particles comprising water-insoluble or only sparingly water-soluble active substance(s), said particles being coated with one or more layers, the outermost layer comprising as principal component one or more hydrophobic powdering agents on which at least one dispersant is absorbed. The invention also relates to a process for producing these particles and to the use thereof in food supplements, foodstuffs, animal feeds, personal-care products, and medicaments.

Dust-free cold-water-dispersible preparations

The present invention relates to a pulverulent vitamin formulation in which the vitamin essentially has a particle size of less than 0.7 &#x3bc;m and which comprises an effective amount of propyl gallate, and also to processes for producing this formulation, and to formulations obtainable by these processes and to the use thereof as animal feed, food, food supplement, personal care product or pharmaceutical composition. The formulations of the invention have improved stability compared to the prior art.

Propyl gallate-containing vitamin preparations

The present invention relates to a novel process for the preparation of pantolactone by reaction of hydroxypivalaldehyde cyanohydrin in a phase separation process.

Preparation of pantolactone

The present invention relates to an improved method for producing all-E astaxanthin dimethyldisuccinate of the formula I. 

Method for producing astaxanthin dimethyldisuccinate

A column is described for carrying out reactive distillations in the presence of a heterogeneous particulate catalyst having an ordered packing or random packings which form intermediate spaces in the column interior, the quotient of the hydraulic diameter for the gas flow through the ordered packing or the random packings and the equivalent diameter of the catalyst particles being in the range from 2 to 20, preferably in the range from 5 to 10, in such a manner that the catalyst particles are introduced into the intermediate spaces, distributed and discharged loose under the action of gravity.

Device and method for carrying out heterogeneously-catalysed reactive distillations in particular for the production of pseudoionone

A process is proposed for the distillation or reactive distillation of a mixture that includes at least one toxic component, the process being carried out in a column containing a structured packing, having at least one packing layer () having a lower end () and an upper end (), the packing layer having an internal geometry varying over its height, in such a manner that in the distillation or reactive distillation, in a first, lower region () of the packing layer () a bubbling layer having a predominantly disperse gas phase can be established and simultaneously in a second, upper region () of the packing layer () a film flow having a predominantly continuous gas phase can be established.

Method for carrying out the distillation or reactive distillation of a mixture containing at least one toxic constituent

The present invention relates to a process for preparing tetrahydrogeranylacetone (tetrahydropseudoionone) by aldol condensation of citral with acetone and subsequent hydrogenation. The invention further relates to the use of thus obtained tetrahydro-geranylacetone for preparing phytol, isophytol, tocopherol and/or tocopherol derivatives. In addition, the invention relates to processes for preparing tocopherols and/or tocopherol derivatives.

Method for the production of tetrahydrogeranylacetone

A process is described for preparing tetrahydrogeranylacetone in which pseudoionone, geranylacetone and/or dihydrogeranylacetone in a liquid phase, in which particles of a catalyst which is capable of preferentially hydrogenating carbon-carbon double bonds over carbon-oxygen double bonds are suspended, is conducted through a device which inhibits the transport of the catalyst particles in the presence of a hydrogen-containing gas.

A dividing-wall column having a dividing wall which is essentially disposed along the long direction of the column is proposed, which divides the column interior into a feed part, a take off part, an upper shared column part and a lower shared column part, with feed in whole or in part in the vaporous state of a mixture to be separated between the upper region of the feed part and the lower region of the feed part and/or side stream take off in whole or in part in the vaporous state between the upper region of the take off part and the lower region of the take off part, where if feed is in whole or in part in the vaporous state the cross-sectional area of the upper region of the feed part is increased by plane-parallel displacement of the dividing wall toward the upper region of the take off part, and/or if the side stream take off is in whole or in part in the vaporous state, the cross-sectional area of the lower region of the take off part is increased by displacement of the dividing wall toward the lower region of the feed part, in such a manner that the F factor is substantially the same in all column regions.

Dividing-wall column with feed in whole or in part in the vaporous state and/or side stream take off in whole or in part in the vaporous state

The invention relates to a continuous process for producing pseudoionones of general formulas (I) and (I') as well as isomers thereof, whereby: Rrepresents CHor (a); Rand Rrepresent hydrogen, CHor CH, and; Rand Rrepresent hydrogen or CH. These pseudoionones are produced by reacting an aldehyde of formula (II) with an excess of a ketone of general formula (III), whereby R, Rand Rhave the aforementioned meanings, in the presence of water and alkali hydroxide at an increased temperature and in a homogeneous solution. The inventive process is characterized in that: a) the intermixing of the homogeneous solution consisting of aldehyde, ketone and aqueous alkali lye occurs at a temperature ranging from 10 to 120&#xb0; C.; b) the undissolved water and alkali hydroxide contained in the reaction mixture are subsequently separated out; c) while avoiding back mixing, the homogeneous reaction mixture is then guided through a reactor, which permits a residence time ranging from 2 to 300 minutes, at a temperature that is 10 to 120&#xb0; C. higher than the boiling point of the lowest-boiling component and under a vapor pressure p ranging from 10to 10Pa; d) the reaction mixture is cooled by expansion; e) ketone is removed from the reaction mixture using vapor flowing in the opposite direction and; f) the raw product is dried and rid from excessive aldehyde and secondary components via a rectification column 

Continuous process for producing pseudoionones and ionones

A supported catalyst is proposed comprising one or more metal oxides as active component on a catalyst support for carrying out an aldol condensation, with the catalyst support being &#x3b3;-aluminum oxide, the active component comprising one or more oxides of the elements having atomic numbers 39 or from 57 to 71 and the concentration of the active component being in the range from 5 to 12% by weight, based on the weight of the catalyst support.

Supported metal oxides as catalysts for aldol condensations

Higher &agr;,&bgr;-unsaturated alcohols are prepared by monoethynylation of a ketone by the NH /KOH method, if desired hydrogenation of the acetylene alcohol in the presence of hydrogen over a Pd-containing thin layer catalyst, purifying distillation of the hydrogenation product, preferably in a dividing wall column with recirculation of the unreacted ketone to the ethynylation step, and, if desired, preparation of higher alcohols having in each case 5 more carbon atoms in the chain by reacting the alcohols prepared by monoethynylation and, if desired, partial hydrogenation with alkyl acetoacetates diketene in a Carroll reaction to form ketones and using these as starting materials for the steps ethynylation, optional hydrogenation and fractional distillation.

Preparation of higher &agr;, &bgr;-unsaturated alcohols

A process for preparing a compound of the formula I

Process for producing substituted indanones

A process for preparing polyenecarbonyl compounds having a high all-E content and their acetals or ketals by aldol condensation or Horner-Emmons reaction comprises carrying out the reaction, for the purposes of the preferred formation of a double bond of E configuration and in order to maintain the E configuration of the double bonds in the stating compounds as completely as possible, in the presence of oxygen or an oxygen-inert gas mixture or nitric oxide or a nitric oxide-inert gas mixture and/or in the presence of specific stable radicals and/or in the presence of quinones or quinone derivatives.

Preparation of polyenecarbonyl compounds having a high content of the

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Heidelberg, Germany

Walter Dobler