Universita′ Degli Studi Di Udine

Innovation Factory S.r.l.

Johnson Matthey Public Limited Company

Universita Degli Studi Di

Universtia Degli Studi Di Udine

Universita' Delgi Studi Di Udine

Bracco Imaging S.p.a.

Serichim S.r.l.

Walter Baratta

Antonio Zanotti-Gerosa

Hans Guenter Nedden

Federica Buonsanti

Pietro Delogu

Salvatore Baldino

Steven Giboulot

Pierluigi Rigo

Katia Siega

Giorgio Adolfo Chelucci

Maurizio Ballico

Santo Magnolia

Micaela Toniutti

Ilaria Adamo

Shuanming Zhang

Rosario Figliolia

The invention relates to monocarbonyl complexes of ruthenium and osmium with bi- and tridentate nitrogen and phosphine ligands. The invention relates to methods for preparing these complexes and the use of these complexes, isolated or prepared in situ, as catalysts for reduction reactions of ketones and aldehydes both via transfer hydrogenation or hydrogenation with hydrogen.

Monocarbonyl ruthenium and osmium catalysts

The disclosure relates to dicarbonyl complexes of ruthenium and osmium with bi- and tridentate nitrogen and phosphine ligands. The disclosure relates to methods for preparing these complexes and the use of these complexes, isolated or prepared in situ, as catalysts for reduction reactions of ketones and aldehydes both via transfer hydrogenation or hydrogenation with hydrogen.

Dicarbonyl ruthenium and osmium catalysts

The present invention relates to improved processes for the preparation of ruthenium or osmium complexes comprising acetate ligands, in particular, ruthenium complexes.

Processes for preparing and using ruthenium and osmium complexes

A new class of ligands derived from benzo[h]quinoline are described and these ligands are used to prepare several novel transition metal complexes. The complexes are preferably of the group VIII transition metals iron, ruthenium or osmium, with the benzo[h]quinolone ligands acting as tridentate ligands. The complexes described are proved to be very active catalysts for the reduction of ketones and aldehydes to alcohols, via hydrogen transfer and hydrogenation reactions. These compounds hence can be usefully employed as catalysts in said reduction reactions.

Ligands of the benzo [H] quinoline class and transition metal complexes containing them and use of said complexes as catalysts

A new class of ligands derived from benzo[h]quinoline are described and these ligands are used to prepare several novel transition metal complexes. The complexes are preferably of the group VIII transition metals iron, ruthenium or osmium, with the benzo[h]quinoline ligands acting as tridentate ligands. The complexes described are proved to be very active catalysts for the reduction of ketones and aldehydes to alcohols, via hydrogen transfer and hydrogenation reactions. These compounds hence can be usefully employed as catalysts in said reduction reactions.

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The invention relates to a new class of ruthenium (II) complexes containing as ligands 2-(aminomethyl)pyridines and phosphines, proven to be extremely active catalysts in the reduction of ketones to alcohols via hydrogen transfer. By using 2-propanol as the hydrogen source with the ruthenium complexes, high yields of the corresponding alcohol can be rapidly obtained starting from linear and cyclic alkyl aryl, dialkyl and diaryl ketones. The conversion of ketones to alcohols can reach 100% if operating in a gaseous hydrogen atmosphere (2-3 atm). Where the phosphines used are optically active, starting from prochiral ketone compounds various types of optically active alcohols can be produced, being important intermediates in the pharmaceutical industry, in the agrochemical industry and for fine chemicals generally.

Complexes of ruthenium with 2-(aminomethyl)pyridines and phosphines, their preparation and use as catalysts

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Udine, Italy

Walter Baratta