Hoechst Aktiengesellschaft

Walter Aumuller

Rudi Weyer

Helmut Weber

Karl Muth

Volker Hitzel

Felix Helmut Schmidt

Ruth Heerdt

Erich Haack

A benzene-sulfonyl semicarbazide of the formula ##STR1## wherein R is such as phenyl and substituted phenyl, cyclohexyl or alkyl, Y is -CH.sub.2 CH.sub.2 - or ##STR2## is alkylene-imino of 3 to carbon atoms which may also be substituted; a representative compound is 4-[4-(.beta.-&lt;2-methoxy-5-chloro-benzamido-&gt;-ethyl)-benzene-sulfonyl]-1,1- (.gamma.,.gamma.-dimethyl-pentamethylene)-semicarbazide.

Benzene-sulfonyl semicarbazides and process for preparing them

Benzenesulfonyl-ureas of the formula ##STR1## wherein X represents ##STR2## IN WHICH Z represents hydrogen, halogen, a trifluormethyl group, an alkyl or an alkoxyl radical in 4- or 5-position, or ##STR3## Y represents --CH.sub.2 --CH.sub.2 --, --CH--(CH.sub.3)--CH.sub.2 --or --CH.sub.2 --CH--(CH.sub.3)--, R represents a radical of

Benzenesulfonyl-ureas and process for preparing them

Sulfonyl-ureas of the formula ##STR1## wherein X represents a heteroaromatic 5- or 6-ring substituted, if desired, by one or two methyl groups and/or annellated with benzene, which ring may contain in addition to a nitrogen atom a further nitrogen, oxygen or sulfur atom and which, in vicinal position to the nitrogen atom, is linked to the rest of the molecule portion, R is alkyl having 1 to 3 carbon atoms, R.sup.1 is alkyl having 3 to 6 carbon atoms, cycloalkyl, alkylcycloalkyl, cycloalkylalkyl, cycloalkenyl, alkylcycloalkenyl having each 5 to 9 carbon atoms, cyclohexenylmethyl, chlorocyclohexyl, bicycloheptenylmethyl, bicycloheptylmethyl, bicycloheptenyl, bicycloheptyl, nortricyclyl, adamantyl, benzyl, which as substance or in form of the salts thereof have hypoglycemic properties and are distinguished by a strong and continuous lowering of the blood sugar level, process for preparing them as well as pharmaceutical preparations containing the sulfonyl-ureas as an active substance.

Benzenesulfonyl-ureas

Sulfonyl-ureas of the formula X--CO--NH--A--SO.sub.2 --NH--CO--NH--R.sup.1, in which R.sup.1 represents cyclopentylmethyl, alkyl-cyclopentylmethyl or dialkyl-cyclopentylmethyl, having up to 2 carbon atoms in the alkyl rest, or cyclopentylethyl, X represents a. ##SPC1## In which R.sup.2 represents hydrogen, F, Cl, Br, CF.sub.3, CH.sub.3 or OCH.sub.3, b. ##SPC2## In which R.sup.3 represents hydrogen, Cl or CH.sub.3, c. ##SPC3## In which R.sup.4 represents hydrogen, Cl or Br, A represents one of the groupings ##SPC4## And their physiologically tolerated salts, process for preparing them and pharmaceutical preparations containing them.

Substituted quinoline-8-carboxamido ethyl benzene-sulfonyl

Benzene sulfonyl ureas of the formula ##SPC1## In which

Benzene sulfonyl ureas

Sulfonamidopyrimidines of the formula ##SPC1## In which X is a 6-membered heteroaromatic ring including 1 to 2 nitrogen atoms which may be substituted with 1 or 2 methyl groups and/or fused with benzene and is linked in vicinal position with regard to the nitrogen atom to the rest of the molecule,

Hypoglycemic benzenesulfonamido pyrimidines

Hypoglycemically active benzenesulfonyl-semicarbazides of the formula ##SPC1## Wherein X is hydrogen, chlorine, bromine, methyl or methoxy, Y is --CH(CH.sub.3)-CH.sub.2 --, preferably --CH.sub.2 --CH.sub.2 --, Z is hydrogen or a hydrocarbon radical of 1 or 2 carbon atoms, which forms together with Y a 5- or 6-membered ring, R is alkylene-imino of 3 to 7 carbon atoms in the ring which may be unsaturated or substituted by 1 or 2 methyl or lower alkyl or methoxy, pentamethylene-imino substituted by endoalkylene of 1 to 3 carbon atoms, hexamethylene-imino substituted by endoethylene in .beta.- .epsilon.-position, tetrahydro-iso-indoline, 4,7-endoalkylenehexahydro- or -tetrahydro-iso-indoline, the endoalkylene containing 1 or 2 carbon atoms and the double bond of the tetrahydro compound being in 5,6-position, and the salts thereof as pharmaceutical preparations for oral administration and lowering of blood sugar level in the treatment of diabetes mellitus and the process for lowering the blood sugar level in the treatment of diabetes mellitus.

Benzenesulfon YL-semicarbazides for lowering blood sugar levels

Benzenesulfonyl-ureas having hypoglycemic activity and corresponding to the formula ##SPC1## Wherein R.sup.1 is

Benzenesulfonyl ureas

N-[4-(.beta.-&lt;2-methoxy-5-chloro-benzamido&gt;-ethyl)-benzenesulfonyl]-N'-cycl opentyl-urea of the formula ##SPC1## Having a long-lasting and strong hypoglycemic action in the treatment of diabetes mellitus and a process for its manufacture.

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Kelkheim (Taunus), Germany

Walter Aumuller