United States of America, as Represented by the Secretary of Agriculture

Sonomaceuticals, LLC

The University of Mississippi

Dow Global Technolgoies LLC

United States Department of Agriculture

Wallace H Yokoyama

Torey James Arvik

Hyunsook Kim

Agnes M Rimando

Scott A Young

Scott R Forsberg

Rebecca Susan Lipson

Dennis R Feller

Stephanie Lynch

Syed Hussain Imam

Jerry R Conklin

Shao-Ching Hung

Bor-Sen Chiou

Maciej Turowski

Yun-Jeong Hong

Stephanie K Lynch

The present disclosure relates to health benefits of Chardonnay seed products.

Therapeutic use of chardonnay seed products

Embodiments described herein provide for uses of grape products, such as Chardonnay grape products and grape seed flour, for use in promoting a healthy liver, promoting healthy fat content in a liver, for treating or preventing NAFLD, and other embodiments and uses as described herein.

Sauvignon blanc grape seed products for nonalcoholic fatty liver disease

Embodiments described herein provide for uses of grape products, such as Chardonnay and Pinot Noir grape products and grape seed flour, for use in promoting a healthy liver, promoting healthy fat content in a liver, for treating or preventing NAFLD, and other embodiments and uses as described herein.

Pinot noir grape products for nonalcoholic fatty liver disease and other uses

Chardonnay grape seed products for nonalcoholic fatty liver disease

A method for and product of the low temperature extrusion of food grade HPMC by sequential addition of powdered HPMC with or without starch is disclosed herein.

Extrusion of high density hydroxypropylmethylcellulose edible flexible gels

Resveratrol has been reported to have hypolipidemic properties. We investigated whether resveratrol and its analogs: pterostilbene, piceatannol and resveratrol trimethyl ether, would activate the peroxisome proliferator-activated receptor alpha (PPAR&#x3b1;) isoform. This nuclear receptor is proposed to mediate the activity of lipid-lowering drugs such as the fibrates. The four stilbenes and ciprofibrate (positive control) were evaluated for the activation of endogenous PPAR&#x3b1; in H4IIEC3 cells transfected with a luciferase gene reporter construct. Pterostilbene demonstrated the highest induction of PPAR&#x3b1;; the maximal response to pterostilbene was similar to that obtained with the hypolipidemic drug, ciprofibrate.

Pterostilbene as an agonist for the peroxisome proliferator-activated receptor alpha isoform

Resveratrol, a stilbenoid antioxidant found in grapes, wine, peanuts and other berries, has been reported to have hypolipidemic properties. Resveratrol and its three analogs (pterostilbene, piceatannol and resveratrol trimethyl ether) were evaluated for their effects on the activation of the peroxisome proliferator-activated receptor alpha (PPAR&#x3b1;) isoforms, a receptor shown to mediate the activity of lipid-lowering drugs such as the fibrates. The four stilbenes and ciprofibrate (positive control) were evaluated for the activation of endogenous PPAR&#x3b1; in H4IIEC3 cells. Pterostilbene demonstrated the highest induction of PPAR&#x3b1; demonstrating increases of 7- and 9-14 fold relative to control. The maximal responses to pterostilbene are similar to those obtained with the hypolipidemic drug, ciprofibrate; that is, pterostilbene acts as a PPAR&#x3b1; agonist, like that of the fibrate class, and is a more effective hypolipidemic agent than resveratrol.

Growing community of inventors

Albany, CA, United States of America

Wallace H Yokoyama